Shoshina Irina I, Almeida Natalia L, Oliveira Milena E C, Trombetta Bianca N T, Silva Gabriella M, Fars Julien, Santos Natanael A, Fernandes Thiago P
Pavlov Institute of Physiology, RAS, Laboratory of Vision Physiology, Saint-Petersburg, Russia; St. Petersburg State University, Institute for Cognitive Research, Saint-Petersburg, Russia.
Department of Psychology, Federal University of Paraiba, Joao Pessoa, Brazil; Perception, Neuroscience and Behaviour Laboratory, Federal University of Paraiba, Brazil.
Psychiatry Res. 2022 Apr;310:114443. doi: 10.1016/j.psychres.2022.114443. Epub 2022 Feb 13.
Bipolar (BPD) patients have deficits in cognition, but there are still controversies about the effects of some medications on their cognitive performance. Here, we investigated the relationship between cognition in terms of executive functions, memory, and attention in both first-episode medication-naive BPD patients and BPD patients taking olanzapine. Forty-one healthy controls, 40 unmedicated drug-naive BPD patients, and 34 BPD patients who took only olanzapine were recruited for the study. Cognitive performance was assessed using the Flanker test, Stroop test, and Corsi-block test. Bayesian multivariate regression analysis was run considering maximum robustness to avoid bias and to predict the outcomes. Our results revealed that unmedicated medication-naive BPD patients performed worse than healthy controls and the olanzapine group in some tasks. Additionally, BPD patients who took olanzapine had better cognitive performance than healthy controls and unmedicated BPD patients. The acute cognitive effects were predicted by olanzapine dosage and serum levels (i.e., large effects). The potential pro-cognitive effects of olanzapine in BPD patients should be carefully interpreted by considering various other clinical variables. We expect that our findings will contribute to further research in this area, with the goal of helping other researchers, patients, and the population.
双相情感障碍（BPD）患者存在认知缺陷，但某些药物对其认知表现的影响仍存在争议。在此，我们研究了首发未用药的BPD患者和服用奥氮平的BPD患者在执行功能、记忆和注意力方面的认知之间的关系。本研究招募了41名健康对照者、40名未用药的初发BPD患者以及34名仅服用奥氮平的BPD患者。使用Flanker测试、Stroop测试和Corsi方块测试评估认知表现。进行贝叶斯多元回归分析，以考虑最大稳健性，避免偏差并预测结果。我们的结果显示，未用药的初发BPD患者在某些任务中的表现比健康对照者和奥氮平组差。此外，服用奥氮平的BPD患者的认知表现优于健康对照者和未用药的BPD患者。奥氮平剂量和血清水平（即显著影响）可预测急性认知效应。应通过考虑各种其他临床变量来谨慎解读奥氮平在BPD患者中潜在的促认知作用。我们期望我们的研究结果将有助于该领域的进一步研究，目标是帮助其他研究人员、患者和公众。
