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甲状腺切除术后九年出现甲状腺嗜酸细胞性细胞聚集体皮下植入。一例病例报告。

Subcutaneous implantation of oncocytic thyroid cell aggregates nine years later from thyroidectomy. A case report.

作者信息

Famà Fausto, Pino Antonella, Cavallari Vittorio, Fadda Guido, Ieni Antonio, Dionigi Gianlorenzo

机构信息

Division for Endocrine and Minimally Invasive Surgery, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University Hospital G. Martino, University of Messina, Messina, Italy.

Division for Endocrine and Minimally Invasive Surgery, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University Hospital G. Martino, University of Messina, Messina, Italy.

出版信息

Int J Surg Case Rep. 2022 Apr;93:106935. doi: 10.1016/j.ijscr.2022.106935. Epub 2022 Mar 10.

Abstract

INTRODUCTION AND IMPORTANCE

Subcutaneous implantation of thyroid tissue is a rare clinical condition that involves the head and neck region and occurs after surgery, diagnostic procedures or cervical trauma.

CASE PRESENTATION

A 90-year old woman with two skin nodules on her thyroidectomy scar was hospitalized and treated by two surgical excisions. Histologically, these lesions were two aggregates of cutaneous oncocytic thyroid cells. In the patient's clinical history there was a total thyroidectomy for multinodular goiter, performed 9 years previously and at which a well-encapsulated subcapsular oncocytic adenoma of the left lobe was also incidentally discovered. At 12 months of follow-up, the patient is showed well and her wounds healed.

CLINICAL DISCUSSION

Subcutaneous colonization or seeding of thyroid tissue is a rare occurrence reported in the literature for both benign and malignant pathologies; among the malignant ones, the implantation of follicular carcinoma cells is the most frequent. Only in one previous case, to our knowledge, subcutaneous colonization originating from oncocytic thyroid (or Hurthle) cell neoplasms has been described.

CONCLUSION

We report an unusual case of double subcutaneous implantation of oncocytic thyroid cells on the cervical scar of an elderly woman, nine years after total thyroidectomy.

摘要

引言与重要性

甲状腺组织皮下植入是一种罕见的临床情况,累及头颈部区域,发生于手术、诊断性操作或颈部创伤之后。

病例介绍

一名90岁女性,甲状腺切除术后瘢痕处有两个皮肤结节,入院后接受了两次手术切除治疗。组织学检查显示,这些病变为皮肤嗜酸性甲状腺细胞的两个聚集物。患者既往史中有9年前因多结节性甲状腺肿行甲状腺全切术,术中还意外发现左叶有一个包膜完整的包膜下嗜酸性腺瘤。随访12个月时,患者情况良好,伤口愈合。

临床讨论

甲状腺组织的皮下定植或播散在文献中报道的良性和恶性病变中均较为罕见;在恶性病变中,滤泡癌细胞的植入最为常见。据我们所知,此前仅有一例报道描述了起源于嗜酸性甲状腺(或许特莱)细胞瘤的皮下定植。

结论

我们报告了一例罕见病例,一名老年女性在甲状腺全切术后9年,颈部瘢痕处出现嗜酸性甲状腺细胞的双重皮下植入。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/65fd/8924621/2ab68d3f19f6/gr1.jpg

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