Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai 201620, China.
Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai 201620, China; Key Lab of Science & Technology of Eco-textile, Ministry of Education, Donghua University, North Ren Min Road 2999, Shanghai 201620, China.
Carbohydr Polym. 2022 Jun 1;285:119218. doi: 10.1016/j.carbpol.2022.119218. Epub 2022 Feb 4.
Bacterial nanocellulose (BNC) is an excellent candidate biomaterial for wound dressing applications, although its preparation should consider the differences in wound healing resulting from BNC biosynthesized by different bacterial strains. This study design aimed to characterize the BNC produced by three different bacterial strains and compare their effectiveness for wound healing applications. The results demonstrated that the upper surfaces of the BNC membranes were clearly denser and more compact than the lower surfaces, while all varieties were capable of serving as a physical barrier to the invasion of bacteria. The growth of fibroblasts demonstrated that the lower surfaces of BNC membranes exhibited biocompatibility superior to that of the upper surfaces. In vivo analysis indicated that, of all samples, wounds treated with the BNC membrane synthesized by DHU-WX-1 displayed the greatest wound repair efficacy. The results indicate that BNC biosynthesized by different strains displayed different wound healing effectiveness. Placing the lower surface of BNC membranes in contact with wounds, with the denser upper surface outward, satisfied the clinical requirements of a wound repair biomaterial.
细菌纳米纤维素（BNC）是一种优秀的伤口敷料应用候选生物材料，但其制备应考虑到不同细菌菌株合成的 BNC 所导致的伤口愈合差异。本研究旨在对三种不同细菌菌株合成的 BNC 进行表征，并比较它们在伤口愈合应用中的效果。结果表明，BNC 膜的上表面明显比下表面更致密和紧凑，而所有品种都能够作为细菌入侵的物理屏障。成纤维细胞的生长表明，BNC 膜的下表面具有优于上表面的生物相容性。体内分析表明，在所有样品中，用 DHU-WX-1 合成的 BNC 膜处理的伤口显示出最大的伤口修复效果。结果表明，不同菌株合成的 BNC 显示出不同的伤口愈合效果。将 BNC 膜的下表面与伤口接触，将较致密的上表面朝外，满足了伤口修复生物材料的临床要求。
