海藻硫酸多糖在骨再生中的作用：系统评价。

Role of sulfated polysaccharides from seaweeds in bone regeneration: A systematic review.

机构信息

Laboratory of Molecular and Genomic Biology, Department of Biology and Genetics, Center of Biosciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil; Postgraduate Program in Biotechnology (RENORBIO), Federal University of Rio Grande do Norte, Natal, RN, Brazil.

Laboratory of Molecular and Genomic Biology, Department of Biology and Genetics, Center of Biosciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil.

出版信息

Carbohydr Polym. 2022 May 15;284:119204. doi: 10.1016/j.carbpol.2022.119204. Epub 2022 Jan 31.

DOI:10.1016/j.carbpol.2022.119204

PMID:35287916

Abstract

Studies on the effect of sulfated polysaccharides from seaweed on bone regeneration have increased in recent years. However, there is no consensus on how to use them and their real effectiveness in that process. Thereby, we carried out a systematic review to answer the question "Do the sulfated polysaccharides from seaweeds promote osteogenesis?". Searches were performed in Pubmed, Scopus, and Web of Knowledge databases. A total of 599 articles were selected, resulting in 14 eligible studies. Results showed that the sulfated polysaccharides from seaweeds increase the osteogenic markers evaluated. Nevertheless, due to the lack of standardization on protocols used, the results should be cautiously interpreted. In addition, studies using animal models are still scarce, and the results with cellular models cannot always be extrapolated to systems that are more complex. Despite the study limitations, the use of sulfated polysaccharides appears to promote in vitro osteogenesis and enhance bone regeneration.

摘要

近年来，关于海藻硫酸多糖对骨再生影响的研究有所增加。然而，关于如何使用它们以及它们在该过程中的实际效果，尚未达成共识。因此，我们进行了系统评价，以回答“海藻硫酸多糖是否能促进成骨？”这个问题。在 Pubmed、Scopus 和 Web of Knowledge 数据库中进行了检索。共选择了 599 篇文章，最终有 14 篇符合纳入标准。结果表明，海藻硫酸多糖可增加评估的成骨标志物。然而，由于所用方案缺乏标准化，因此应谨慎解释结果。此外，使用动物模型的研究仍然很少，细胞模型的结果并不总是可以外推到更复杂的系统。尽管存在研究局限性，但使用硫酸多糖似乎可促进体外成骨和增强骨再生。