Ariga K
Hokkaido Igaku Zasshi. 1978;53(2):133-46.
Pigmented rabbits were sensitized by subcutaneous injection of BCG together with Freund's complete adjuvant and heat killed tubercle bacilli together with adjuvant. After the titer of serum antibody to BGG was elevated or tuberculin skin test became positive, choroiditis was induced in these eyes by an injection of BGG or PPD directly through the posterior sclera in the vicinity of the optic nerve. The eyes were enucleated at various intervals and the choroid was studied by light and electron microscopy. In the choroid challenged with BGG, infiltrates such as polymorphonuclear leukocytes and lymphocytes were seen, in early stages, invading in the posterior segment and peripheral area near the ciliary body. These cells decreased in number within a few days, and after one week a few plasma cells were detected in the posterior uvea. In the choroid challenged with PPD, infiltration of monocytes and lymphocytes was seen in early stages, reaching its peak in 48 hours. After 4 and 5 days lymphocytes decreased in number, but monocytes showed mitotic and phagocytotic activity, and accumulated near the sclera. After one week typical epithelioid cells were detected along the suprachoroidal space. These events were restricted within the choroid. The results obtained suggest, that in the focal immune reaction of the choroid, the cellular sequence of events and the range of tissue involved are different depending upon the kinds of antigen used. It may indicate humoral immunity on one side and cell-mediate immunity on the other.
将色素沉着的兔子通过皮下注射卡介苗（BCG）与弗氏完全佐剂以及热灭活的结核杆菌与佐剂一起进行致敏。在血清抗BCG抗体滴度升高或结核菌素皮肤试验呈阳性后，通过直接经视神经附近的后巩膜注射BCG或结核菌素纯蛋白衍生物（PPD），在这些眼睛中诱发脉络膜炎。在不同时间间隔摘除眼球，并通过光学显微镜和电子显微镜对脉络膜进行研究。在用BCG攻击的脉络膜中，早期可见多形核白细胞和淋巴细胞等浸润物侵入后段和睫状体附近的周边区域。这些细胞在几天内数量减少，一周后在后葡萄膜中检测到少量浆细胞。在用PPD攻击的脉络膜中，早期可见单核细胞和淋巴细胞浸润，在48小时达到高峰。4天和5天后淋巴细胞数量减少，但单核细胞表现出有丝分裂和吞噬活性，并在巩膜附近聚集。一周后，沿脉络膜上腔检测到典型的上皮样细胞。这些事件局限于脉络膜内。所得结果表明，在脉络膜的局部免疫反应中，根据所用抗原的种类，细胞事件序列和所涉及的组织范围有所不同。这可能一方面表明体液免疫，另一方面表明细胞介导免疫。
