Department of Prosthodontics and Crown & Bridge, Nitte Deemed to be University, AB Shetty Memorial Institutes of Dental Sciences (ABSMIDS), Mangalore, India.
Department of General Dental Practice, P. O. Box 24923, Kuwait University, Safat, 13110, Kuwait.
Photodiagnosis Photodyn Ther. 2022 Jun;38:102803. doi: 10.1016/j.pdpdt.2022.102803. Epub 2022 Mar 11.
The aim was to assess the role of antimicrobial photodynamic therapy (aPDT) in reducing subgingival oral yeasts colonization (OYC) in patients with peri-implant mucositis (PIM).
Patients diagnosed with PIM were included. Patient demographics were recorded and implant placement and prosthetic rehabilitation protocols were retrieved from patients' records. Peri-implant clinical parameters (modified plaque index [mPI], modified bleeding index [mBI] probing depth [PD]) and subgingival OYC and were assessed using standard techniques. All patients were randomly divided into test- and control-groups. In the test-group, patients underwent mechanical debridement (MD) of implant surfaces and supra and sub-gingival peri-implant sulci peri-implant immediately followed by a single session of aPDT. In the control-group, patients underwent MD alone. Peri-implant clinical parameters and OYC were re-assessed at 3-months' follow-up. Sample-size estimation was done on data from a pilot investigation and group-comparisons were done using the paired t- and Mann Whitney U-tests. Correlation between age, mPI, mBI, PD and OYC at baseline and 3-months' follow-up was assessed using regression analysis models. A statistically significant difference between the groups was recorded when P-values were less than 0.01.
Thirty-four individuals (17 and 17 in the test- and control groups, respectively) were included. There was no significant difference in the mean age, scores of mPI, mBI, PD and OYC among patients in the test- and control-groups at baseline. At 3-months of follow-up, there was a statistically significant reduction in scores of mPI (P<0.001), mBI (P<0.001), PD (P<0.001) and OYC (P<0.001) among patients in the test- compared with the control-groups. There was no significant correlation between age, mPI, mBI, PD and OYC in both groups.
In the short term, a single session of aPDT as an adjunct to MD is effective in reducing peri-implant soft tissue inflammation and OYC in patients with PIM.
评估抗菌光动力疗法（aPDT）在减少种植体周围黏膜炎（PIM）患者龈下口腔酵母菌定植（OYC）中的作用。
纳入诊断为 PIM 的患者。记录患者人口统计学数据，并从患者记录中检索种植体放置和修复体康复方案。使用标准技术评估种植体周围临床参数（改良菌斑指数[mPI]、改良出血指数[mBI]、探诊深度[PD]）和龈下 OYC。所有患者均随机分为试验组和对照组。在试验组中，患者在种植体表面和龈上及龈下种植体周围沟进行机械清创（MD），随后立即进行单次 aPDT。在对照组中，患者仅进行 MD。在 3 个月的随访时重新评估种植体周围临床参数和 OYC。根据初步研究的数据进行样本量估计，并使用配对 t 检验和曼-惠特尼 U 检验进行组间比较。使用回归分析模型评估基线和 3 个月随访时年龄、mPI、mBI、PD 和 OYC 之间的相关性。当 P 值小于 0.01 时，记录组间存在统计学显著差异。
共纳入 34 名患者（试验组和对照组各 17 名）。试验组和对照组患者的平均年龄、mPI、mBI、PD 和 OYC 评分在基线时无显著差异。在 3 个月的随访时，与对照组相比，试验组患者的 mPI（P<0.001）、mBI（P<0.001）、PD（P<0.001）和 OYC（P<0.001）评分均有统计学显著降低。两组患者的年龄、mPI、mBI、PD 和 OYC 之间均无显著相关性。
短期内，MD 联合单次 aPDT 可有效减少 PIM 患者种植体周围软组织炎症和 OYC。
