磷酸盐与细胞衰老。
Phosphate and Cellular Senescence.
机构信息
Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Departments of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
出版信息
Adv Exp Med Biol. 2022;1362:55-72. doi: 10.1007/978-3-030-91623-7_7.
Cellular senescence is one type of permeant arrest of cell growth and one of increasingly recognized contributor to aging and age-associated disease. High phosphate and low Klotho individually and synergistically lead to age-related degeneration in multiple organs. Substantial evidence supports the causality of high phosphate in cellular senescence, and potential contribution to human aging, cancer, cardiovascular, kidney, neurodegenerative, and musculoskeletal diseases. Phosphate can induce cellular senescence both by direct phosphotoxicity, and indirectly through downregulation of Klotho and upregulation of plasminogen activator inhibitor-1. Restriction of dietary phosphate intake and blockage of intestinal absorption of phosphate help suppress cellular senescence. Supplementation of Klotho protein, cellular senescence inhibitor, and removal of senescent cells with senolytic agents are potential novel strategies to attenuate phosphate-induced cellular senescence, retard aging, and ameliorate age-associated, and phosphate-induced disorders.
细胞衰老（cellular senescence）是一种细胞生长的永久停滞，也是越来越被认可的衰老和与衰老相关疾病的原因之一。高磷和低 Klotho 单独或协同作用导致多个器官的与年龄相关的退化。大量证据支持高磷在细胞衰老中的因果关系，并可能导致人类衰老、癌症、心血管、肾脏、神经退行性和肌肉骨骼疾病。磷可以通过直接的磷毒性，以及通过下调 Klotho 和上调纤溶酶原激活物抑制剂-1，间接诱导细胞衰老。限制饮食中磷的摄入和阻止肠道对磷的吸收有助于抑制细胞衰老。Klotho 蛋白、细胞衰老抑制剂的补充，以及用 senolytic 剂去除衰老细胞，是减轻磷诱导的细胞衰老、延缓衰老、改善与衰老相关和磷诱导的疾病的潜在新策略。
Zotero 插件