National Clinical Research Center for Geriatric Diseases, Xiangya Hospital of Central South University, Changsha, Hunan, P. R. China.
Eye Center of Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China.
J Cell Physiol. 2022 May;237(5):2357-2373. doi: 10.1002/jcp.30716. Epub 2022 Mar 14.
Polypyrimidine tract-binding protein (PTB), as a member of the heterogeneous nuclear ribonucleoprotein family, functions by rapidly shuttling between the nucleus and the cytoplasm. PTB is involved in the alternative splicing of pre-messenger RNA (mRNA) and almost all steps of mRNA metabolism. PTB regulation is organ-specific; brain- or muscle-specific microRNAs and long noncoding RNAs partially contribute to regulating PTB, thereby modulating many physiological and pathological processes, such as embryonic development, cell development, spermatogenesis, and neuron growth and differentiation. Previous studies have shown that PTB knockout can inhibit tumorigenesis and development. The knockout of PTB in glial cells can be reprogrammed into functional neurons, which shows great promise in the field of nerve regeneration but is controversial.
多嘧啶 tract 结合蛋白 (PTB) 作为核不均一核糖核蛋白家族的一员，通过在核和细胞质之间快速穿梭发挥作用。PTB 参与前信使 RNA (mRNA) 的选择性剪接和 mRNA 代谢的几乎所有步骤。PTB 的调节具有器官特异性；脑或肌肉特异性 microRNAs 和长非编码 RNA 部分有助于调节 PTB，从而调节许多生理和病理过程，如胚胎发育、细胞发育、精子发生以及神经元生长和分化。先前的研究表明，PTB 敲除可以抑制肿瘤的发生和发展。胶质细胞中 PTB 的敲除可以被重新编程为功能性神经元，这在神经再生领域具有很大的应用前景，但存在争议。
