Department of Restorative Dentistry, Niğde Ömer Halisdemir University, Niğde, Turkey.
Department of Pediatric Dentistry, Mersin University, Mersin, Turkey.
Diabetes Metab Res Rev. 2022 Jul;38(5):e3527. doi: 10.1002/dmrr.3527. Epub 2022 Mar 28.
This study aimed to conduct a meta-analysis by synthesising the outcomes of studies that investigated the relationship between type 1 diabetes (T1D) and salivary flow rate (SFR), salivary pH (SpH), salivary buffer capacity (SBC), streptococcus Mutans (SM), and lactobacillus (LB) counts.
The PRISMA statement guide was followed for the meta-analysis. Electronic databases were searched, and study selection and data collection processes were performed. The risks of bias in individual studies and across studies were assessed. Mean differences (MD) and Odds Ratio (OR) were used to measure the effect estimates in the comparisons.
29 studies were included in the qualitative and quantitative syntheses. Significantly higher SFR (MD = -0.22, CI: -0.26, -0.18; p < 0.001) and SpH (MD = -0.59, CI: -0.81, -0.36; p < 0.001) were observed in the healthy individuals than T1D individuals. No significant difference was observed among groups in terms of SBC (MD = 0.10, CI: -0.46,0.66; p = 0.73). An increased odds ratio of SM counts were observed regarding the T1D (OR = 3.09, 95% CI: 1.16, 8.20; p = 0.02). No association was found between LB counts and T1D (OR = 2.15, 95% CI: 0.38, 11.98; p = 0.38).
Subjects with T1D have a significantly lesser SFR and SpH than healthy individuals. But no significant difference is available in terms of SBC. Lower SM counts were observed in individuals with T1D, while no association was observed regarding LB counts. The tendency to dental caries is more likely in subjects with T1D due to lower SFR, SpH, and higher SM.
本研究旨在通过综合研究 1 型糖尿病（T1D）与唾液流量（SFR）、唾液 pH 值（SpH）、唾液缓冲能力（SBC）、变形链球菌（SM）和乳杆菌（LB）计数之间关系的研究结果来进行荟萃分析。
本研究遵循 PRISMA 声明指南进行荟萃分析。检索电子数据库，并进行研究选择和数据收集过程。评估了个体研究和跨研究的偏倚风险。采用均数差（MD）和比值比（OR）来衡量比较中的效应估计值。
定性和定量综合分析共纳入 29 项研究。与 T1D 个体相比，健康个体的 SFR（MD=-0.22，CI：-0.26，-0.18；p<0.001）和 SpH（MD=-0.59，CI：-0.81，-0.36；p<0.001）明显更高。各组之间 SBC（MD=0.10，CI：-0.46，0.66；p=0.73）无显著差异。T1D 个体中 SM 计数的优势比增加（OR=3.09，95%CI：1.16，8.20；p=0.02）。LB 计数与 T1D 之间无关联（OR=2.15，95%CI：0.38，11.98；p=0.38）。
与健康个体相比，T1D 个体的 SFR 和 SpH 明显较低，但 SBC 无显著差异。T1D 个体的 SM 计数较低，而 LB 计数无关联。由于 SFR、SpH 降低和 SM 升高，T1D 患者发生龋齿的趋势更高。
