韩国特发性肺动脉高压的回顾性基于人群的生存研究。
A Retrospective Population-Based Survival Study of Idiopathic Pulmonary Arterial Hypertension in Korea.
机构信息
Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Division of Cardiology, Department of Pediatrics, Adult Congenital Heart Clinic, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
出版信息
J Korean Med Sci. 2022 Mar 14;37(10):e80. doi: 10.3346/jkms.2022.37.e80.
BACKGROUND
Few studies used nationwide data to assess the survival rates (SRs) and death risk for idiopathic pulmonary arterial hypertension (IPAH; ICD-10 I27.0) in Korea.
METHODS
IPAH data (N = 9,017; female:male = 6:4) were collected from the National Health Insurance Service in Korea, from 2006 through 2017. The data consisted of primary diagnoses related to IPAH. The Kaplan-Meier method and Cox proportional-hazards analyses were carried out.
RESULTS
The mean age was 62.3 (± 19.4) years, 64.2 (± 18.9) years in female and 59.4 (± 19.8) years in male ( < 0.001). The one-, three-, five- and 10-year SRs for IPAH were 89.0%, 79.8%, 72.3% and 57.0%, respectively. The adjusted hazard ratio (HR) of IPAH was 1.81 (95% confidence interval [CI], 1.26-2.59) in 60-69 age group, 3.42 (95% CI, 2.40-4.87) in 70-79, and 7.73 (95% CI, 5.43-11.0) in 80s. Other risk factors were male, low-income status, diabetes, myocardial infarction, atrial fibrillation, ischemic stroke, hemorrhagic stroke, and malignant neoplasm.
CONCLUSION
The 10-year SR of IPAH was 57% in Korea. The HR for IPAH was significantly high in patients with older age and other risk factors.
背景
很少有研究使用全国性数据来评估韩国特发性肺动脉高压 (IPAH；ICD-10 I27.0) 的生存率 (SRs) 和死亡风险。
方法
从韩国国家健康保险服务处收集了 2006 年至 2017 年期间 IPAH 数据（N = 9017；女性：男性 = 6:4）。数据包括与 IPAH 相关的主要诊断。采用 Kaplan-Meier 方法和 Cox 比例风险分析。
结果
平均年龄为 62.3（±19.4）岁，女性为 64.2（±18.9）岁，男性为 59.4（±19.8）岁（<0.001）。IPAH 的一年、三年、五年和十年 SR 分别为 89.0%、79.8%、72.3%和 57.0%。60-69 岁年龄组 IPAH 的调整后风险比 (HR) 为 1.81（95%置信区间 [CI]，1.26-2.59），70-79 岁为 3.42（95% CI，2.40-4.87），80 岁及以上为 7.73（95% CI，5.43-11.0）。其他危险因素包括男性、低收入状况、糖尿病、心肌梗死、心房颤动、缺血性卒中和出血性卒中和恶性肿瘤。
结论
韩国 IPAH 的 10 年 SR 为 57%。年龄较大和其他危险因素的 IPAH HR 明显较高。
Zotero 插件