Department of Cardiology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.
Cardiovascular Department, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Libyan J Med. 2022 Dec;17(1):2028997. doi: 10.1080/19932820.2022.2028997.
The relation between dietary minerals and coronary artery calcification (CAC) has been emphasized. However, the effects of multiple dietary minerals on CAC progression remain unclear. This study Investiagetes the effect of combined dietary mineral intake on the progression of CAC. We analyzed a population-based cohort with 6814 participants from the Multi-Ethnic Study of Atherosclerosis (MESA). CAC scores were measured at baseline and subsequent follow-up examinations by Multi-detector computed tomography (MDCT) scans with Agatston scores. Then, the progression of CAC was defined through increased CAC scores in the follow-up from the baseline exam. The results revealed that the dietary intake of individual minerals did not show significant differences across CAC progression vs non progression groups. However, participants with CAC progression had an increased Magnesium (Mg):Zinc (Zn) ratio ( < 0.05). This effect was significant in logistic regression after adjusting for multiple established risk factors of CAC progression (OR 1.050; 95% CI 1.003, 1.099; = 0.038). The increased risk of CAC associated with Mg/Zn was mediated through an increase level of IL-6, which increased with association to the Mg: Zn ratio. In conclusion, the dietary of Mg: Zn ratio, rather than individual mineral intake is associated with increased risk of CAC progression, which is mediated by pro-calcific IL-6. Therefore, the consideration of dietary intake of Zn and Mg together would play a cardio protective role among CAC patients.
膳食矿物质与冠状动脉钙化（CAC）之间的关系已得到强调。然而，多种膳食矿物质对 CAC 进展的影响仍不清楚。本研究旨在探讨联合膳食矿物质摄入对 CAC 进展的影响。我们分析了来自动脉粥样硬化多民族研究（MESA）的一个基于人群的队列，该队列有 6814 名参与者。CAC 评分在基线和随后的多探测器 CT（MDCT）扫描时通过 Agatston 评分进行测量。然后，通过基线检查后的随访中 CAC 评分的增加来定义 CAC 的进展。结果表明，在 CAC 进展与非进展组之间，个体矿物质的膳食摄入量没有显著差异。然而，CAC 进展的参与者的镁（Mg）：锌（Zn）比值增加（<0.05）。在调整 CAC 进展的多个既定危险因素后，这种影响在逻辑回归中具有统计学意义（OR 1.050；95%CI 1.003，1.099；=0.038）。与 Mg/Zn 相关的 CAC 增加风险是通过增加与 Mg: Zn 比值相关的 IL-6 水平来介导的。总之，Mg: Zn 比值的膳食摄入，而不是个体矿物质的摄入与 CAC 进展的风险增加相关，这是通过促钙化的 IL-6 介导的。因此，考虑 Zn 和 Mg 的膳食摄入相结合可能在 CAC 患者中发挥心脏保护作用。
