Hruby Adela, O'Donnell Christopher J, Jacques Paul F, Meigs James B, Hoffmann Udo, McKeown Nicola M
Nutritional Epidemiology Program, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts.
National Heart, Lung, and Blood Institute (NHLBI) Division of Intramural Research, and NHLBI's Framingham Heart Study, Framingham, Massachusetts; Cardiovascular Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.
JACC Cardiovasc Imaging. 2014 Jan;7(1):59-69. doi: 10.1016/j.jcmg.2013.10.006. Epub 2013 Nov 27.
The aim of this study was to examine whether magnesium intake is associated with coronary artery calcification (CAC) and abdominal aortic calcification (AAC).
Animal and cell studies suggest that magnesium may prevent calcification within atherosclerotic plaques underlying cardiovascular disease. Little is known about the association of magnesium intake and atherosclerotic calcification in humans.
We examined cross-sectional associations of self-reported total (dietary and supplemental) magnesium intake estimated by food frequency questionnaire with CAC and AAC in participants of the Framingham Heart Study who were free of cardiovascular disease and underwent Multi-Detector Computed Tomography (MDCT) of the heart and abdomen (n = 2,695; age: 53 ± 11 years), using multivariate-adjusted Tobit regression. CAC and AAC were quantified using modified Agatston scores (AS). Models were adjusted for age, sex, body mass index, smoking status, systolic blood pressure, fasting insulin, total-to-high-density lipoprotein cholesterol ratio, use of hormone replacement therapy (women only), menopausal status (women only), treatment for hyperlipidemia, hypertension, cardiovascular disease prevention, or diabetes, as well as self-reported intake of calcium, vitamins D and K, saturated fat, fiber, alcohol, and energy. Secondary analyses included logistic regressions of CAC and AAC outcomes as cut-points (AS >0 and AS ≥90th percentile for age and sex), as well as sex-stratified analyses.
In fully adjusted models, a 50-mg/day increment in self-reported total magnesium intake was associated with 22% lower CAC (p < 0.001) and 12% lower AAC (p = 0.07). Consistent with these observations, the odds of having any CAC were 58% lower (p trend: <0.001) and any AAC were 34% lower (p trend: 0.01), in those with the highest compared to those with the lowest magnesium intake. Stronger inverse associations were observed in women than in men.
In community-dwelling participants free of cardiovascular disease, self-reported magnesium intake was inversely associated with arterial calcification, which may play a contributing role in magnesium's protective associations in stroke and fatal coronary heart disease.
本研究旨在探讨镁摄入量是否与冠状动脉钙化（CAC）和腹主动脉钙化（AAC）相关。
动物和细胞研究表明，镁可能预防心血管疾病潜在动脉粥样硬化斑块内的钙化。关于镁摄入量与人类动脉粥样硬化钙化之间的关联知之甚少。
我们在弗雷明汉心脏研究中，对无心血管疾病且接受心脏和腹部多排计算机断层扫描（MDCT）的参与者（n = 2695；年龄：53±11岁），使用多变量调整的 Tobit 回归，研究了通过食物频率问卷估计的自我报告的总（饮食和补充）镁摄入量与 CAC 和 AAC 的横断面关联。使用改良的阿加斯顿评分（AS）对 CAC 和 AAC 进行量化。模型针对年龄、性别、体重指数、吸烟状况、收缩压、空腹胰岛素、总胆固醇与高密度脂蛋白胆固醇比值、激素替代疗法的使用（仅女性）、绝经状态（仅女性）、高脂血症治疗、高血压、心血管疾病预防或糖尿病，以及自我报告的钙、维生素 D 和 K、饱和脂肪、纤维、酒精和能量摄入量进行了调整。二次分析包括将 CAC 和 AAC 结果作为切点（年龄和性别特异性的 AS>0 和 AS≥第 90 百分位数）的逻辑回归，以及按性别分层的分析。
在完全调整的模型中，自我报告的总镁摄入量每天增加 50 毫克与 CAC 降低 22%（p<0.001）和 AAC 降低 12%（p = 0.07）相关。与这些观察结果一致，与镁摄入量最低者相比，镁摄入量最高者发生任何 CAC 的几率降低 58%（p 趋势：<0.001），发生任何 AAC 的几率降低 34%（p 趋势：0.01）。在女性中观察到的负相关比男性更强。
在无心血管疾病的社区居住参与者中，自我报告的镁摄入量与动脉钙化呈负相关，这可能在镁对中风和致命性冠心病的保护关联中起作用。
