Hastings M H, Herbert J
Neurosci Lett. 1986 Aug 15;69(1):1-6. doi: 10.1016/0304-3940(86)90404-0.
The paraventriculo-spinal projection of the Syrian hamster was characterized by retrograde labelling of neuronal perikarya in the paraventricular nucleus of the hypothalamus (PVN) following injection of True blue tracer into the intermediolateral cell column of the thoracic spinal cord. Injection of the excitatory neurotoxin, N-methyl-D,L-aspartic acid into the region of the PVN spared magnocellular neurones and fibres of passage but destroyed parvocellular neurones of the paraventriculo-spinal pathway. Hamsters bearing complete bilateral lesions of the parvocellular PVN failed to show the typical nocturnal increase in pineal melatonin content. These data indicate the importance of the paraventriculo-spinal projection in the central control of pineal melatonin synthesis.
通过将真蓝示踪剂注入叙利亚仓鼠胸段脊髓中间外侧细胞柱，对其下丘脑室旁核（PVN）的室旁 - 脊髓投射进行了特征研究，结果显示PVN中神经元胞体出现逆行标记。向PVN区域注射兴奋性神经毒素N - 甲基 - D，L - 天冬氨酸，可使大细胞神经元和传导纤维免受损伤，但会破坏室旁 - 脊髓通路的小细胞神经元。双侧小细胞PVN完全损伤的仓鼠未表现出松果体褪黑素含量典型的夜间增加。这些数据表明室旁 - 脊髓投射在松果体褪黑素合成的中枢控制中具有重要作用。
