Brown M H, Badura L L, Nunez A A
Neurosci Lett. 1987 Jan 14;73(2):103-8. doi: 10.1016/0304-3940(87)90001-2.
Controversy exists concerning the sensitivity of neurons of the paraventricular nucleus (PVN) of the hypothalamus to the toxic effects of N-methyl aspartic acid (NMA). To further investigate this problem, male golden hamsters (Mesocricetus auratus) received unilateral intrahypothalamic injections of NMA, coupled with injections of horseradish peroxidase into the area of the spinal cord which receives projections from the PVN. Histological evaluation of the brains showed that the NMA injections destroyed PVN neurons that project to the spinal cord. These results are discussed in reference to previous reports on the effects of NMA injections on photoperiod-dependent seasonal cycles in hamsters.
关于下丘脑室旁核（PVN）神经元对N-甲基天冬氨酸（NMA）毒性作用的敏感性存在争议。为了进一步研究这个问题，雄性金黄地鼠（Mesocricetus auratus）接受了下丘脑内单侧注射NMA，并在接受PVN投射的脊髓区域注射辣根过氧化物酶。对大脑的组织学评估表明，NMA注射破坏了投射到脊髓的PVN神经元。结合之前关于NMA注射对仓鼠光周期依赖性季节性周期影响的报告对这些结果进行了讨论。
