Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.
Microbiol Immunol. 2022 Jun;66(6):324-329. doi: 10.1111/1348-0421.12976. Epub 2022 Apr 12.
It is obvious that genetic differences, including mutations and polymorphisms, can play an important role in viral infections. In this case-control study, which included 81 human T-cell leukemia virus type 1 (HTLV-1) asymptomatic carriers (AC) and 162 healthy controls (HC), the rs4143815 polymorphism of PDL1 gene was investigated. This polymorphism is the site of miR-570 binding and it can influence immune system responses. The rs4143815 polymorphism was evaluated by allele-specific polymerase chain reaction (AS-PCR) and the proviral load levels by quantitative real-time PCR (q PCR). The results demonstrated that the C allele (P = 0.027) and the CC genotype (P = 0.031) of rs4143815 polymorphism was significantly higher in the AC group than in the HC group, also the proviral load in the AC group with the C allele (P = 0.020) was significantly higher. Thus, the rs4143815 polymorphism can play a vital role in HTLV-1 infection.
很明显，遗传差异，包括突变和多态性，可能在病毒感染中发挥重要作用。在这项包括 81 例人类 T 细胞白血病病毒 1 型（HTLV-1）无症状携带者（AC）和 162 例健康对照（HC）的病例对照研究中，研究了 PDL1 基因的 rs4143815 多态性。该多态性是 miR-570 结合的位点，可影响免疫系统反应。通过等位基因特异性聚合酶链反应（AS-PCR）评估 rs4143815 多态性，通过定量实时 PCR（qPCR）评估前病毒载量水平。结果表明，rs4143815 多态性的 C 等位基因（P=0.027）和 CC 基因型（P=0.031）在 AC 组中显著高于 HC 组，AC 组中具有 C 等位基因的前病毒载量（P=0.020）也显著升高。因此，rs4143815 多态性在 HTLV-1 感染中可能起重要作用。
