SARChI Research Chair in Pathogenic Yeasts, Department of Microbiology and Biochemistry, University of the Free state, Bloemfontein, South Africa.
Infect Immun. 2022 Apr 21;90(4):e0005722. doi: 10.1128/iai.00057-22. Epub 2022 Mar 15.
Interaction between microbes may influence antimicrobial susceptibility of one or more of the microbes, with studies pointing to increased resistance in these scenarios. Hattab et al. provided a novel perspective by identifying synergism between fluconazole and bacterial antagonism in the context of Candida albicans-Pseudomonas aeruginosa co-infection. Further research is required to translate these findings to the clinical setting, especially in the era of increasing antifungal resistance.
微生物之间的相互作用可能会影响一种或多种微生物的抗菌敏感性，研究表明在这些情况下会增加耐药性。Hattab 等人通过在白色念珠菌-铜绿假单胞菌合并感染的情况下发现氟康唑和细菌拮抗作用之间的协同作用，提供了一个新的视角。需要进一步的研究将这些发现转化到临床环境中，特别是在抗真菌药物耐药性日益增加的时代。
