新型 8-羟基喹啉衍生物对耐甲氧西林金黄色葡萄球菌的抗菌和协同活性。
Antibacterial and synergistic activity of a new 8-hydroxyquinoline derivative against methicillin-resistant .
机构信息
Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, 90610-000, Brazil.
Programa de Pós-graduação em Microbiologia Agrícola e do Ambiente, Universidade Federal do Rio Grande do Sul, Porto Alegre, 90050-170, Brazil.
出版信息
Future Microbiol. 2022 Apr;17:425-436. doi: 10.2217/fmb-2021-0198. Epub 2022 Mar 15.
To evaluate the antibacterial and synergistic effect of a new 8-hydroxyquinoline derivative (PH176) against MRSA. PH176 activity was determined by broth microdilution against 38 clinical isolates. The antibacterial and synergistic effects with oxacillin and nitroxoline were evaluated by time-kill assays to five MRSA isolates. Toxicity was evaluated by and models. The MIC and MIC of PH176 were 16 and 32 μg/ml, respectively. The PH176 and nitroxoline led to a reduction in colony count for four isolates and the combination of PH176 and oxacillin acted synergically for three isolates. Furthermore, PH176 was determined to be noncytotoxic/nonirritant. These results demonstrate that PH176 has revealed promising results to be a potential candidate to treat MRSA infections.
为了评估新型 8-羟基喹啉衍生物（PH176）对耐甲氧西林金黄色葡萄球菌（MRSA）的抗菌和协同作用。通过肉汤微量稀释法对 38 株临床分离株测定 PH176 的活性。采用时间杀伤试验评估 PH176 与苯唑西林和硝呋太尔的协同抗菌作用，对 5 株 MRSA 分离株进行评估。通过 和 模型评估毒性。PH176 的 MIC 和 MIC 分别为 16 和 32μg/ml。PH176 和硝呋太尔导致 4 株分离株的菌落计数减少，PH176 和苯唑西林的组合对 3 株分离株表现出协同作用。此外，PH176 被确定为非细胞毒性/非刺激性。这些结果表明，PH176 具有治疗 MRSA 感染的潜在候选药物的良好前景。
Zotero 插件