Department of Epidemiology and Evaluation, Hospital del Mar Medical Research Institute (IMIM), Passeig Marítim, 25-29, 08003, Barcelona, Spain.
Preventive Medicine and Public Health Teaching Unit (Hospital del Mar - Barcelona Public Health Agency - Pompeu Fabra University), Barcelona, Spain.
Breast Cancer Res Treat. 2022 Jun;193(2):455-465. doi: 10.1007/s10549-022-06563-x. Epub 2022 Mar 15.
To identify adherence to follow-up recommendations in long-term breast cancer survivors (LTBCS) of the SURBCAN cohort and to identify its determinants, using real-world data.
We conducted a retrospective study using electronic health records from 2012 to 2016 of women diagnosed with incident breast cancer in Spain between 2000 and 2006 and surviving at least 5 years. Adherence to basic follow-up recommendations, adherence according to risk of recurrence, and overall adherence were calculated based on attendance at medical appointments and imaging surveillance, by year of survivorship. Logistic regression models were fitted to depict the association between adherence and its determinants.
A total of 2079 LTBCS were followed up for a median of 4.97 years. Of them, 23.6% had survived ≥ 10 years at baseline. We estimated that 79.5% of LTBCS were overall adherent to at least one visit and one imaging test. Adherence to recommendations decreased over time and no differences were found according to recurrence risk. Determinants of better overall adherence were diagnosis in middle age (50-69 years old), living in a more-deprived area, having fewer years of survival, receiving primary treatment, and being alive at the end of follow-up.
We identified women apparently not complying with surveillance visits and tests. Special attention should be paid to the youngest and eldest women at diagnosis and to those with longer survival.
利用真实世界的数据，确定 SURBCAN 队列中长期乳腺癌幸存者（LTBCS）对随访建议的依从性，并确定其决定因素。
我们对 2000 年至 2006 年间在西班牙被诊断患有乳腺癌且至少存活 5 年的女性进行了一项回顾性研究，使用的是 2012 年至 2016 年的电子健康记录。根据就诊和影像学监测情况，按生存年限计算基本随访建议的依从性、根据复发风险的依从性和总体依从性。通过逻辑回归模型来描述依从性及其决定因素之间的关联。
共对 2079 名 LTBCS 进行了中位随访时间为 4.97 年的随访。其中，23.6%的患者在基线时已存活≥10 年。我们估计，79.5%的 LTBCS 至少接受了一次就诊和一次影像学检查。随着时间的推移，建议的依从性下降，但根据复发风险无差异。更好的总体依从性的决定因素是中年（50-69 岁）诊断、生活在较贫困地区、生存年限较短、接受初级治疗和随访结束时存活。
我们发现一些女性显然不遵守监测就诊和检查的建议。应特别关注诊断时最年轻和最年长的女性以及生存时间较长的女性。
