Álvarez-Salvago Francisco, Medina-Luque Jose, Figueroa-Mayordomo Maria, Pujol-Fuentes Clara, Atienzar-Aroca Sandra, Jiménez-García José Daniel, Gutiérrez-García Palmira, Estornut Cristina, Molina-García Cristina
FIBIO Research Group, Department of Physiotherapy, Faculty of Health Sciences, European University of Valencia, 46010, Valencia, Spain.
Department of Health Sciences, Faculty of Health Sciences, University of Jaén, 23071, Jaén, Spain.
J Cancer Surviv. 2025 Jun 2. doi: 10.1007/s11764-025-01819-z.
The aim of this study was to explore the association between different levels of self-perceived muscular strength and health status among long-term breast cancer survivors (LTBCSs), as well as to determine the factors that predict self-perceived muscular strength during this phase of long-term survivorship.
A cross-sectional study was conducted with 80 LTBCSs, classified into three groups based on self-perceived muscular strength levels: very poor/poor (1-2), average (3), and good/very good (4-5). Variables analyzed, measured ≥ 5 years post-diagnosis, included other aspects of physical fitness, physical activity (PA) levels, pain, cancer-related fatigue (CRF), mood state, and health-related quality of life (HRQoL). ANOVA, Mann-Whitney U, and chi-square tests were performed, along with correlation and multiple regression analysis. Cohen's d was used to calculate effect sizes.
Among LTBCSs, 37.5% reported very poor/poor self-perceived muscular strength, 32.5% average, and 30% good/very good levels. Participants with lower self-perceived muscular strength exhibited declines in physical fitness, greater inactivity, higher pain levels, elevated CRF, mood disturbances, and reduced HRQoL (all p < 0.05). Regression analysis identified "general physical fitness" (β = 0.32; p = 0.01), "cardiorespiratory endurance" (β = 0.40; p < 0.01), "global health status" (β = 0.16; p = 0.04), and "breast symptoms" (β = - 0.16; p = 0.04) as significant predictors of higher self-perceived muscular strength (r adjusted = .573).
Good/very good levels of self-perceived muscular strength were observed in just 30% of LTBCSs. Those with lower self-perceived muscular strength exhibited more significant physical, mental, and emotional decline ≥ 5 years post-diagnosis. The combination of "general physical fitness," "cardiorespiratory endurance," "global health status," and "breast symptoms" accounts for 57.3% of the variance in self-perceived muscular strength levels among LTBCSs.
Targeted interventions addressing self-perceived muscular strength could help mitigate long-term physical and emotional sequelae.
本研究旨在探讨长期乳腺癌幸存者（LTBCSs）自我感知的不同肌肉力量水平与健康状况之间的关联，并确定在长期生存阶段预测自我感知肌肉力量的因素。
对80名LTBCSs进行了一项横断面研究，根据自我感知的肌肉力量水平将其分为三组：非常差/差（1 - 2）、中等（3）、良好/非常好（4 - 5）。分析的变量在确诊后≥5年进行测量，包括身体素质的其他方面、身体活动（PA）水平、疼痛、癌症相关疲劳（CRF）、情绪状态和健康相关生活质量（HRQoL）。进行了方差分析、曼 - 惠特尼U检验和卡方检验，以及相关性和多元回归分析。使用科恩d值计算效应大小。
在LTBCSs中，37.5%报告自我感知的肌肉力量非常差/差，32.5%为中等，30%为良好/非常好。自我感知肌肉力量较低的参与者在身体素质方面表现出下降，活动更少，疼痛水平更高，CRF升高，情绪紊乱，HRQoL降低（所有p < 0.05）。回归分析确定“总体身体素质”（β = 0.32；p = 0.01）、“心肺耐力”（β = 0.40；p < 0.01）、“整体健康状况”（β = 0.16；p = 0.04）和“乳房症状”（β = - 0.16；p = 0.04）是自我感知肌肉力量较高的显著预测因素（调整后r = 0.573）。
仅30%的LTBCSs自我感知的肌肉力量处于良好/非常好水平。自我感知肌肉力量较低的患者在确诊后≥5年表现出更显著的身体、心理和情绪衰退。“总体身体素质”、“心肺耐力”、“整体健康状况”和“乳房症状”的组合占LTBCSs自我感知肌肉力量水平方差的57.3%。
针对自我感知肌肉力量的有针对性干预措施可能有助于减轻长期的身体和情绪后遗症。
