Labouta Hagar I, Langer Robert, Cullis Pieter R, Merkel Olivia M, Prausnitz Mark R, Gomaa Yasmine, Nogueira Sara S, Kumeria Tushar
College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, R3E 0T5, Canada.
Biomedical Engineering, University of Manitoba, Winnipeg, MB, Canada.
Drug Deliv Transl Res. 2022 Nov;12(11):2581-2588. doi: 10.1007/s13346-022-01146-1. Epub 2022 Mar 15.
The triumphant success of mRNA vaccines is a testimony to the important role drug delivery technologies have played in protecting billions of people against SARS-CoV-2 (or the Corona Virus Disease 2019; COVID-19). Several lipid nanoparticle (LNP) mRNA vaccines were developed and have been instrumental in preventing the disease by boosting the immune system against the pathogen, SARS-CoV-2. These vaccines have been built on decades of scientific research in drug delivery of mRNA, vaccines, and other biologicals. In this manuscript, several leading and emerging scientists in the field of drug delivery share their perspective on the role of drug delivery technologies in developing safe and efficacious vaccines, in a roundtable discussion. The authors also discussed their viewpoint on the current challenges, and the key research questions that should drive this important area of research.
信使核糖核酸（mRNA）疫苗的巨大成功证明了药物递送技术在保护数十亿人免受严重急性呼吸综合征冠状病毒2（或2019冠状病毒病；COVID-19）侵害方面所发挥的重要作用。几种脂质纳米颗粒（LNP）mRNA疫苗已被研发出来，通过增强免疫系统对病原体严重急性呼吸综合征冠状病毒2的抵抗力，在预防该疾病方面发挥了重要作用。这些疫苗建立在数十年关于mRNA、疫苗及其他生物制品药物递送的科学研究基础之上。在本手稿中，药物递送领域的几位顶尖和新兴科学家在一次圆桌讨论中分享了他们对于药物递送技术在研发安全有效的疫苗中所起作用的看法。作者们还讨论了他们对当前挑战以及推动这一重要研究领域的关键研究问题的观点。
