Sydney School of Veterinary Science, Faculty of Science, The University of Sydney, RMC Gunn Building (B19), Sydney, NSW 2006, Australia.
J Nutr Sci. 2022 Feb 21;11:e13. doi: 10.1017/jns.2022.11. eCollection 2022.
Since the discovery of vitamin D, it has been accepted that its physiological supply is either from food or by endogenous synthesis in skin exposed to solar UV light. Yet vitamin D is a component of very few foods and its supply as a natural nutrient is unable to maintain good vitamin D status for human populations. One aspect of vitamin D physiology that has been ignored is that the mechanisms for its transport and processing from these two sources are quite different. Excess intake of vitamin D causes hypercalcaemic toxicity. However, experiments with different animal species have shown that long-term supply of oral vitamin D in apparently non-toxic amounts causes atherosclerosis in large arteries. A mechanism for this toxicity is proposed. Alternative strategies for addressing widespread vitamin D deficiency by food fortification should be considered in light of the angiotoxicity caused by oral vitamin D in animal experiments.
自从发现维生素 D 以来，人们一直认为其生理供应要么来自食物，要么来自皮肤暴露在太阳紫外线中内源性合成。然而，维生素 D 是极少数食物的成分，作为一种天然营养素，它无法为人类提供良好的维生素 D 状态。维生素 D 生理学中被忽视的一个方面是，其从这两个来源的运输和处理机制有很大的不同。过量摄入维生素 D 会导致高钙血症毒性。然而，不同动物物种的实验表明，长期口服给予看似无毒剂量的维生素 D 会导致大动脉粥样硬化。提出了这种毒性的一种机制。鉴于动物实验中口服维生素 D 引起的血管毒性，应该考虑通过食物强化来解决广泛的维生素 D 缺乏的替代策略。
