Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Atherogenomics Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Obes Rev. 2022 Jul;23(7):e13444. doi: 10.1111/obr.13444. Epub 2022 Mar 15.
Obesity derives from an extended period of positive energy imbalance due to a complex interplay of environmental and biological factors. Muscle fiber type and physiology have been hypothesized to affect metabolism and energy expenditure and thus to affect an individual's propensity to gain weight. However, there have been conflicting reports regarding a relationship between muscle fiber type and obesity. Here, we systematically reviewed literature investigating this topic from PubMed, Web of Science, and EMBASE. Of these, 32 articles were included in our final review and analysis. Most studies (22/32) reported a significant relationship between muscle fiber-type proportion and a measure of obesity. Overall, there was a significant negative relationship between the proportion of type I fibers and body mass index (BMI) and a significant positive relationship between the proportion of type IIX fibers and BMI. Moreover, between-group comparisons indicated a greater prevalence of type IIX fibers and a lower prevalence of type I fibers in patients living with obesity relative to lean individuals. These significant relationships were confirmed in a meta-analysis of these data. The causal nature of these associations remains to be evaluated.
肥胖是由于环境和生物因素的复杂相互作用导致的长期能量正平衡引起的。肌肉纤维类型和生理学被假设会影响代谢和能量消耗，从而影响个体的体重增加倾向。然而，关于肌肉纤维类型与肥胖之间的关系，一直存在相互矛盾的报告。在这里，我们从 PubMed、Web of Science 和 EMBASE 系统地回顾了调查这一主题的文献。其中，32 篇文章被纳入我们的最终综述和分析。大多数研究（22/32）报告了肌肉纤维类型比例与肥胖衡量指标之间存在显著关系。总体而言，I 型纤维比例与体重指数（BMI）呈显著负相关，而 IIX 型纤维比例与 BMI 呈显著正相关。此外，组间比较表明，与瘦个体相比，肥胖患者中 IIX 型纤维的患病率更高，而 I 型纤维的患病率更低。这些数据的荟萃分析证实了这些显著的相关性。这些关联的因果性质仍有待评估。
