Plana Emma, Oto Julia, Medina Pilar, Herranz Raquel, Fernández-Pardo Álvaro, Requejo Lucia, Miralles Manuel
Angiology and Vascular Surgery Service, La Fe University and Polytechnic Hospital, Valencia, Spain.
Haemostasis, Thrombosis, Arteriosclerosis and Vascular Biology Research Group, Medical Research Institute Hospital La Fe, Valencia, Spain.
IUBMB Life. 2022 Oct;74(10):982-994. doi: 10.1002/iub.2610. Epub 2022 Mar 16.
Thrombospondins are a family of matricellular proteins with a multimeric structure that is known to be involved in several biological and pathological processes. Their relationship with vascular disorders has raised special interest recently. Aortic aneurysms are related to the impairment of vascular remodeling, in which extracellular matrix proteins seem to play an important role. Thus, research in thrombospondins, and their potential role in aneurysm development is progressively gaining importance. Nevertheless, studies showing thrombospondin dysregulation in human samples are still scarce. Although studies performed in vitro and in vivo models are essential to understand the molecular mechanisms and pathways underlying the disorder, descriptive studies in human samples are also necessary to ascertain their real value as biomarkers and/or novel therapeutic targets. The present article reviews the latest findings regarding the role of thrombospondins in aortic aneurysm development, paying particular attention to the studies performed in human samples.
血小板反应蛋白是一类具有多聚体结构的基质细胞蛋白，已知其参与多种生物学和病理过程。它们与血管疾病的关系最近引起了特别关注。主动脉瘤与血管重塑受损有关，其中细胞外基质蛋白似乎起着重要作用。因此，对血小板反应蛋白及其在动脉瘤发展中的潜在作用的研究正变得越来越重要。然而，显示人类样本中血小板反应蛋白失调的研究仍然很少。尽管在体外和体内模型中进行的研究对于理解该疾病的分子机制和途径至关重要，但对人类样本的描述性研究对于确定它们作为生物标志物和/或新型治疗靶点的实际价值也是必要的。本文综述了关于血小板反应蛋白在主动脉瘤发展中作用的最新发现，特别关注在人类样本中进行的研究。
