SPC24 作为肾透明细胞癌和肾乳头状细胞癌的潜在生物标志物用于预测预后和/或免疫浸润的研究。

An Investigation of SPC24 as a Putative Biomarker of Kidney Renal Clear Cell Carcinoma and Kidney Renal Papillary Cell Carcinoma for Predicting Prognosis and/or Immune Infiltration.

机构信息

Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Jiangxi Institute of Urology, Nanchang, China.

出版信息

Comb Chem High Throughput Screen. 2022;25(13):2278-2294. doi: 10.2174/1386207325666220315105054.

DOI:10.2174/1386207325666220315105054

PMID:35293292

Abstract

BACKGROUND AND OBJECTIVE

SPC24 was reported to be correlated with the development of many cancers. However, its role in renal cancer was unclear. Our aim was to explore the role of SPC24 in kidney renal clear cell carcinoma (KIRC) and kidney renal papillary cell carcinoma (KIRP) in types of renal cancer.

METHODS

SPC24 expressions in KIRC and KIRP were firstly analyzed. Subsequently, the correlation between SPC24 expression and TNM staging of KIRC and KIRP and the accuracy of SPC24 in diagnosing KIRC and KIRP were explored. Moreover, the correlation between SPC24 expression and prognosis of KIRC and KIRP were analyzed. Univariate and multivariate analyses were performed to identify prognostic factors in KIRC and KIRP, and nomograms were constructed. The correlation between SPC24 expression and immune cell infiltration, immune molecules, microsatellite instability (MSI), and tumor mutational burden (TMB) were further explored. Finally, the correlations between SPC24 expression and prognosis of KIRC based on different immune cell enrichment were analyzed.

RESULTS

SPC24 was significantly up-regulated in multiple cancers, especially KIRC and KIRP. SPC24 expression was significantly correlated with the TNM stage of KIRC and KIRP, and upregulated SPC24 suggested a worse prognosis. Besides, SPC24 possesses good accuracy in diagnosing KIRC and KIRP. The SPC24-based nomograms displayed satisfactory efficacy in KIRC and KIRP. Moreover, we found that SPC24 expression was closely correlated with immune cell infiltration, immune molecules, and TMB in KIRC, and up-regulated SPC24 revealed poor prognosis based on different immune cell enrichment.

CONCLUSION

SPC24 has the potential to be a biomarker predicting the prognosis and/or immune infiltration of KIRC and KIRP.

摘要

背景与目的

SPC24 被报道与多种癌症的发展相关。然而，其在肾透明细胞癌（KIRC）和肾乳头状细胞癌（KIRP）中的作用尚不清楚。我们的目的是探讨 SPC24 在两种肾癌中的作用。

方法

首先分析 SPC24 在 KIRC 和 KIRP 中的表达。然后，探讨 SPC24 表达与 KIRC 和 KIRP 的 TNM 分期的相关性以及 SPC24 诊断 KIRC 和 KIRP 的准确性。此外，还分析了 SPC24 表达与 KIRC 和 KIRP 预后的相关性。进行单因素和多因素分析以确定 KIRC 和 KIRP 的预后因素，并构建列线图。进一步探讨 SPC24 表达与免疫细胞浸润、免疫分子、微卫星不稳定性（MSI）和肿瘤突变负荷（TMB）的相关性。最后，分析了基于不同免疫细胞富集的 SPC24 表达与 KIRC 预后的相关性。

结果

SPC24 在多种癌症中显著上调，尤其是在 KIRC 和 KIRP 中。SPC24 表达与 KIRC 和 KIRP 的 TNM 分期显著相关，上调的 SPC24 提示预后较差。此外，SPC24 对 KIRC 和 KIRP 的诊断具有良好的准确性。基于 SPC24 的列线图在 KIRC 和 KIRP 中显示出令人满意的疗效。此外，我们发现 SPC24 表达与 KIRC 中的免疫细胞浸润、免疫分子和 TMB 密切相关，上调的 SPC24 根据不同的免疫细胞富集显示出不良的预后。