Department of Medical Microbiology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
J Virol. 2022 Apr 13;96(7):e0009022. doi: 10.1128/jvi.00090-22. Epub 2022 Mar 16.
The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spreads rapidly and harbors many mutations in the spike protein, but the origin of this virus variant remains unclear. We address the role of unusual virus evolution mechanisms such as hypermutation, out-of-frame reading, and recombination. Rather, regular Darwinian evolution, that is, the repeated selection of beneficial spike mutations, seems to have led to the appearance of the grossly altered spike protein of the Omicron variant.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的奥密克戎变体传播迅速，并在刺突蛋白中存在许多突变，但该病毒变体的起源仍不清楚。我们研究了异常病毒进化机制（如超突变、移码阅读和重组）的作用。相反，常规的达尔文进化，即对有益的刺突突变的反复选择，似乎导致了奥密克戎变体中明显改变的刺突蛋白的出现。
