帕金森病和多系统萎缩患者 iPSC 衍生少突胶质细胞表现出α-突触核蛋白诱导的成熟和免疫反应性改变。
Parkinson's disease and multiple system atrophy patient iPSC-derived oligodendrocytes exhibit alpha-synuclein-induced changes in maturation and immune reactive properties.
机构信息
iPSC Laboratory for CNS Disease Modeling, Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden.
Protein Structure and Bioinformatics, Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden.
出版信息
Proc Natl Acad Sci U S A. 2022 Mar 22;119(12):e2111405119. doi: 10.1073/pnas.2111405119. Epub 2022 Mar 16.
SignificanceOur results demonstrate the existence of early cellular pathways and network alterations in oligodendrocytes in the alpha-synucleinopathies Parkinson's disease and multiple system atrophy. They further reveal the involvement of an immune component triggered by alpha-synuclein protein, as well as a connection between (epi)genetic changes and immune reactivity in multiple system atrophy. The knowledge generated in this study could be used to devise novel therapeutic approaches to treat synucleinopathies.
意义我们的研究结果表明，在帕金森病和多系统萎缩等α-突触核蛋白病中，少突胶质细胞中存在早期细胞通路和网络改变。它们进一步揭示了α-突触核蛋白触发的免疫成分的参与，以及多系统萎缩中（表观）遗传变化和免疫反应之间的联系。本研究中产生的知识可用于设计治疗突触核蛋白病的新治疗方法。
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