• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Genetic ancestry in precision medicine is reshaping the race debate.

作者信息

Krainc Talia, Fuentes Agustín

机构信息

Department of Anthropology, Princeton University, Princeton, NJ 08544.

出版信息

Proc Natl Acad Sci U S A. 2022 Mar 22;119(12):e2203033119. doi: 10.1073/pnas.2203033119. Epub 2022 Mar 16.

DOI:10.1073/pnas.2203033119
PMID:35294278
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8944248/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f4/8944248/57964c89738a/pnas.2203033119fig02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f4/8944248/355aa29a8550/pnas.2203033119fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f4/8944248/57964c89738a/pnas.2203033119fig02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f4/8944248/355aa29a8550/pnas.2203033119fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f4/8944248/57964c89738a/pnas.2203033119fig02.jpg

相似文献

1
Genetic ancestry in precision medicine is reshaping the race debate.精准医学中的遗传血统正在重塑种族辩论。
Proc Natl Acad Sci U S A. 2022 Mar 22;119(12):e2203033119. doi: 10.1073/pnas.2203033119. Epub 2022 Mar 16.
2
Conflating race and ancestry: Tracing decision points about population descriptors over the precision medicine research life course.混淆种族和祖先：追溯精准医学研究生命周期中关于人口描述符的决策点。
HGG Adv. 2024 Jan 11;5(1):100243. doi: 10.1016/j.xhgg.2023.100243. Epub 2023 Sep 27.
3
Emerging Concepts in Precision Medicine and Cardiovascular Diseases in Racial and Ethnic Minority Populations.精准医学与少数族裔人群心血管疾病的新观念。
Circ Res. 2019 Jun 21;125(1):7-13. doi: 10.1161/CIRCRESAHA.119.314970. Epub 2019 Jun 20.
4
Neuropharmacological and Neurogenetic Correlates of Opioid Use Disorder (OUD) As a Function of Ethnicity: Relevance to Precision Addiction Medicine.神经药理学和神经遗传学与阿片类药物使用障碍（OUD）的相关性，以及其与种族的关系：对精准成瘾医学的意义。
Curr Neuropharmacol. 2020;18(7):578-595. doi: 10.2174/1570159X17666191118125702.
5
Unequal representation of genetic variation across ancestry groups creates healthcare inequality in the application of precision medicine.遗传变异在不同祖先群体中的分布不均，导致了精准医学应用中的医疗保健不平等。
Genome Biol. 2016 Jul 14;17(1):157. doi: 10.1186/s13059-016-1016-y.
6
Characterizing Race/Ethnicity and Genetic Ancestry for 100,000 Subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) Cohort.在成人健康与衰老基因流行病学研究（GERA）队列中对10万名受试者的种族/民族和基因血统进行特征分析。
Genetics. 2015 Aug;200(4):1285-95. doi: 10.1534/genetics.115.178616. Epub 2015 Jun 19.
7
Undercutting efforts of precision medicine: roadblocks to minority representation in breast cancer clinical trials.破坏精准医学努力：乳腺癌临床试验中少数民族代表性不足的障碍。
Breast Cancer Res Treat. 2021 Jun;187(3):605-611. doi: 10.1007/s10549-021-06264-x. Epub 2021 Jun 2.
8
Clinical Genetics Lacks Standard Definitions and Protocols for the Collection and Use of Diversity Measures.临床遗传学缺乏多样性衡量标准的定义和收集使用的标准规范。
Am J Hum Genet. 2020 Jul 2;107(1):72-82. doi: 10.1016/j.ajhg.2020.05.005. Epub 2020 Jun 6.
9
Bounded Justice, Inclusion, and the Hyper/Invisibility of Race in Precision Medicine.精准医学中的有界正义、包容以及种族的超隐形/隐形
Am J Bioeth. 2023 Jul;23(7):27-33. doi: 10.1080/15265161.2023.2207515. Epub 2023 May 23.
10
Navigating conflicts of justice in the use of race and ethnicity in precision medicine.在精准医学中运用种族和族裔时应对正义冲突
Bioethics. 2020 Oct;34(8):849-856. doi: 10.1111/bioe.12757. Epub 2020 May 19.

引用本文的文献

1
Evaluating Liquid Biopsy for Circulating Tumor DNA (ctDNA) Detection as a Complementary Diagnostic Tool in Thyroid Cancer Among Ecuadorian Women.评估液体活检检测循环肿瘤DNA（ctDNA）作为厄瓜多尔女性甲状腺癌辅助诊断工具的价值。
Int J Mol Sci. 2025 Jul 21;26(14):6987. doi: 10.3390/ijms26146987.
2
Race and ethnicity in fibrotic interstitial lung diseases: what do these categories contribute in the clinical setting?纤维化间质性肺疾病中的种族和族裔：这些类别在临床环境中起到了什么作用？
ERJ Open Res. 2025 Jul 7;11(4). doi: 10.1183/23120541.00034-2025. eCollection 2025 Jul.
3
Diverse Genomes, Shared Health: Insights from a Health System Biobank.

本文引用的文献

1
Getting genetic ancestry right for science and society.为科学和社会准确解析基因谱系。
Science. 2022 Apr 15;376(6590):250-252. doi: 10.1126/science.abm7530. Epub 2022 Apr 14.
2
Prediction of End-Stage Kidney Disease Using Estimated Glomerular Filtration Rate With and Without Race : A Prospective Cohort Study.基于是否考虑种族因素的估算肾小球滤过率预测终末期肾病：一项前瞻性队列研究。
Ann Intern Med. 2022 Mar;175(3):305-313. doi: 10.7326/M21-2928. Epub 2022 Jan 11.
3
Evaluating the Impact and Rationale of Race-Specific Estimations of Kidney Function: Estimations from U.S. NHANES, 2015-2018.
多样基因组，共享健康：来自健康系统生物样本库的见解
medRxiv. 2025 Jun 12:2025.06.11.25329386. doi: 10.1101/2025.06.11.25329386.
4
Exceptional Long-term Response to Immunotherapy in an African American Man With -Mutated Metastatic Lung Adenocarcinoma.一名携带KRAS突变的转移性肺腺癌非裔美国男性对免疫疗法的长期显著反应。
J Investig Med High Impact Case Rep. 2025 Jan-Dec;13:23247096251346830. doi: 10.1177/23247096251346830. Epub 2025 May 31.
5
The clinical and molecular landscape of breast cancer in women of African and South Asian ancestry.非洲和南亚裔女性乳腺癌的临床与分子概况。
Nat Commun. 2025 May 20;16(1):4237. doi: 10.1038/s41467-025-59144-z.
6
Genetic Ancestry and Lung Cancer in Latin American Patients: A Crucial Step for Understanding a Diverse Population.拉丁裔患者的遗传血统与肺癌：了解多样化人群的关键一步。
Clin Lung Cancer. 2025 Jul;26(5):e342-e352. doi: 10.1016/j.cllc.2025.03.004. Epub 2025 Mar 13.
7
Pharmacogenomics of chemotherapy induced peripheral neuropathy using an electronic health record-derived definition: a genome-wide association study.使用电子健康记录衍生定义的化疗诱导周围神经病变的药物基因组学：一项全基因组关联研究
Support Care Cancer. 2025 Apr 8;33(5):362. doi: 10.1007/s00520-025-09392-y.
8
Pharmacogenomic markers associated with drug-induced QT prolongation: a systematic review.与药物性QT间期延长相关的药物基因组学标志物：一项系统综述。
Pharmacogenomics. 2025 Jan-Feb;26(1-2):53-72. doi: 10.1080/14622416.2025.2481025. Epub 2025 Mar 21.
9
Equitable machine learning counteracts ancestral bias in precision medicine.公平的机器学习可抵消精准医学中的祖传偏见。
Nat Commun. 2025 Mar 10;16(1):2144. doi: 10.1038/s41467-025-57216-8.
10
Race and ethnicity matter! Moving Parkinson's risk research towards diversity and inclusiveness.种族和族裔至关重要！推动帕金森病风险研究走向多样性和包容性。
NPJ Parkinsons Dis. 2025 Mar 7;11(1):45. doi: 10.1038/s41531-025-00891-7.
评估种族特异性肾功能估计值的影响及理论依据：来自2015 - 2018年美国国家健康与营养检查调查（NHANES）的估计值
EClinicalMedicine. 2021 Nov 19;42:101197. doi: 10.1016/j.eclinm.2021.101197. eCollection 2021 Dec.
4
Fine-scale genetic ancestry as a potential new tool for precision medicine.精细尺度的遗传血统作为精准医学的一种潜在新工具。
Nat Med. 2021 Jul;27(7):1152-1153. doi: 10.1038/s41591-021-01405-7.
5
The quagmire of race, genetic ancestry, and health disparities.种族、遗传血统与健康差异的困境。
J Clin Invest. 2021 Jun 1;131(11). doi: 10.1172/JCI150255.
6
Toward a fine-scale population health monitoring system.迈向精细化的人口健康监测系统。
Cell. 2021 Apr 15;184(8):2068-2083.e11. doi: 10.1016/j.cell.2021.03.034.
7
Race and Pharmacogenomics-Personalized Medicine or Misguided Practice?种族与药物基因组学——个性化医疗还是错误实践？
JAMA. 2021 Feb 16;325(7):625-626. doi: 10.1001/jama.2020.25473.
8
Evolutionary genetics of skin pigmentation in African populations.非洲人群皮肤色素沉着的进化遗传学。
Hum Mol Genet. 2021 Apr 26;30(R1):R88-R97. doi: 10.1093/hmg/ddab007.
9
Abolish race correction.废除种族校正。
Lancet. 2021 Jan 2;397(10268):17-18. doi: 10.1016/S0140-6736(20)32716-1.
10
Clinical Implications of Removing Race From Estimates of Kidney Function.从估计肾功能的指标中去除种族因素的临床意义。
JAMA. 2021 Jan 12;325(2):184-186. doi: 10.1001/jama.2020.22124.