Inhibiting the P2Y receptor reduces IL-33 and HMGB1 lung concentrations and inflammatory cell infiltration in a murine model of asthma.
作者信息
Li Lanxin, Fuller Stephen J
机构信息
Department of Medicine, Sydney Medical School Nepean, University of Sydney, Nepean Hospital, Penrith, NSW, 2750, Australia.
出版信息
Purinergic Signal. 2022 Dec;18(4):403-405. doi: 10.1007/s11302-022-09859-1. Epub 2022 Mar 16.
Abstract
摘要
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Inhibiting the P2Y receptor reduces IL-33 and HMGB1 lung concentrations and inflammatory cell infiltration in a murine model of asthma.在哮喘小鼠模型中，抑制P2Y受体可降低肺部IL-33和HMGB1的浓度以及炎性细胞浸润。
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本文引用的文献
1
Purinergic Receptors in the Airways: Potential Therapeutic Targets for Asthma?气道中的嘌呤能受体：哮喘的潜在治疗靶点？
Front Allergy. 2021 May 31;2:677677. doi: 10.3389/falgy.2021.677677. eCollection 2021.
2
Targeting the P2Y Receptor Suppresses IL-33 and HMGB1 Release and Ameliorates Experimental Asthma.靶向 P2Y 受体抑制 IL-33 和 HMGB1 的释放并改善实验性哮喘。
Am J Respir Crit Care Med. 2022 Feb 1;205(3):300-312. doi: 10.1164/rccm.202009-3686OC.
3
Purinergic signaling, DAMPs, and inflammation.嘌呤能信号转导、损伤相关分子模式（DAMPs）和炎症。
Am J Physiol Cell Physiol. 2020 May 1;318(5):C832-C835. doi: 10.1152/ajpcell.00053.2020. Epub 2020 Mar 11.
4
The Cytokines of Asthma.哮喘的细胞因子。
Immunity. 2019 Apr 16;50(4):975-991. doi: 10.1016/j.immuni.2019.03.018.
5
Chronic IL-33 expression predisposes to virus-induced asthma exacerbations by increasing type 2 inflammation and dampening antiviral immunity.慢性 IL-33 表达通过增加 2 型炎症和抑制抗病毒免疫来导致病毒诱导的哮喘加重。
J Allergy Clin Immunol. 2018 May;141(5):1607-1619.e9. doi: 10.1016/j.jaci.2017.07.051. Epub 2017 Sep 22.
6
IL-33: biological properties, functions, and roles in airway disease.白细胞介素-33：生物学特性、功能及其在气道疾病中的作用
Immunol Rev. 2017 Jul;278(1):173-184. doi: 10.1111/imr.12552.
7
Gene-based analysis of regulatory variants identifies 4 putative novel asthma risk genes related to nucleotide synthesis and signaling.基于基因的调控变异分析鉴定出4个与核苷酸合成和信号传导相关的推定新型哮喘风险基因。
J Allergy Clin Immunol. 2017 Apr;139(4):1148-1157. doi: 10.1016/j.jaci.2016.07.017. Epub 2016 Aug 20.
8
Aeroallergen-induced IL-33 predisposes to respiratory virus-induced asthma by dampening antiviral immunity.过敏原诱导的白介素 33 通过抑制抗病毒免疫来诱发呼吸道病毒诱导的哮喘。
J Allergy Clin Immunol. 2016 Nov;138(5):1326-1337. doi: 10.1016/j.jaci.2016.02.039. Epub 2016 Apr 25.
9
Heritability and confirmation of genetic association studies for childhood asthma in twins.双胞胎儿童哮喘遗传力和遗传关联研究的验证。
Allergy. 2016 Feb;71(2):230-8. doi: 10.1111/all.12783. Epub 2015 Nov 23.
10
Pathology of asthma.哮喘的病理学
Front Microbiol. 2013 Sep 10;4:263. doi: 10.3389/fmicb.2013.00263.
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