Department of Biotechnology, UIET, Punjab University, Chandigarh, India.
Department of Plant Pathology, University of Minnesota, Saint Paul, MN, 55108, USA.
Mol Biol Rep. 2022 Aug;49(8):8025-8035. doi: 10.1007/s11033-022-07333-0. Epub 2022 Mar 16.
Myo-inositol is one of the most abundant form of inositol. The myo-inositol (MI) serves as substrate to diverse biosynthesis pathways and hence it is conserved across life forms. The biosynthesis of MI is well studied in animals. Beyond biosynthesis pathway, implications of MI pathway and enzymes hold potential implications in plant physiology and crop improvement. Myo-inositol oxygenase (MIOX) enzyme catabolize MI into D-glucuronic acid (D-GlcUA). The MIOX enzyme family is well studied across few plants. More recently, the MI associated pathway's crosstalk with other important biosynthesis and stress responsive pathways in plants has drawn attention. The overall outcome from different plant species studied so far are very suggestive that MI derivatives and associated pathways could open new directions to explore stress responsive novel metabolic networks. There are evidences for upregulation of MI metabolic pathway genes, specially MIOX under different stress condition. We also found MIOX genes getting differentially expressed according to developmental and stress signals in Arabidopsis and wheat. In this review we try to highlight the missing links and put forward a tailored view over myo-inositol oxidation pathway and MIOX proteins.
肌醇是肌醇中最丰富的形式之一。肌醇（MI）作为各种生物合成途径的底物，因此在生命形式中是保守的。MI 的生物合成在动物中得到了很好的研究。除了生物合成途径外，MI 途径和酶的影响在植物生理学和作物改良中具有潜在的意义。肌醇氧化酶（MIOX）酶将 MI 分解为 D-葡萄糖醛酸（D-GlcUA）。MIOX 酶家族在一些植物中得到了很好的研究。最近，MI 相关途径与植物中其他重要的生物合成和应激响应途径的串扰引起了人们的关注。迄今为止，从不同植物物种研究中得出的总体结果非常表明，MI 衍生物和相关途径可能为探索应激响应的新型代谢网络开辟新的方向。有证据表明，在不同的应激条件下，MI 代谢途径基因，特别是 MIOX，会被上调。我们还发现，在拟南芥和小麦中，MIOX 基因根据发育和应激信号的不同而表达差异。在这篇综述中，我们试图强调缺失的环节，并对肌醇氧化途径和 MIOX 蛋白提出有针对性的观点。
