Zhang Yizhe, Chen Sifan, Tian Weitian, Zhu Hui, Li Weiwei, Dai Wanbing, Zhang Xiao, Gu Xiyao, Su Diansan
Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Front Med (Lausanne). 2022 Feb 28;9:817351. doi: 10.3389/fmed.2022.817351. eCollection 2022.
To evaluate sepsis-associated encephalopathy (SAE) research and to quantitatively and qualitatively predict research hot spots using bibliometric analysis.
We extracted relevant publications from the Web of Science Core Collection on July 28, 2021. We investigated the retrieved data by bibliometric analysis (e.g. co-cited and cluster analysis, keyword co-occurrence) using the software CiteSpace and VOSviewer, the Online Analysis Platform of Literature Metrology (http://bibliometric.com/) and Bibliometrix to analyse and predict the trends and hot spots in this field.
We identified 1,582 published articles and reviews on SAE from 2001 to 2021. During this period, the number of manuscripts on SAE increased steadily and peaked in 2021. The USA and China were the leading countries that had a critical impact on SAE research. Among all institutions, Vanderbilt University and Pittsburgh University held leading positions and became central in the collaboration network. Among all the journals, published the maximum number of manuscripts in the field of SAE within 20 years. Dal-Pizzol Felipe was the most productive author (61 papers) and received the largest number of citations (930 citations). Co-citation cluster analysis revealed that the most popular terms on SAE in the manner of cluster labels were critical illness, sepsis-associated encephalopathy, polymicrobial sepsis, posterior reversible encephalopathy syndrome, rat brain, intensive care unit, prior sepsis, molecular hydrogen, inflammation drive, metabolic encephalopathies, delirium pathophysiology, and clinical neuroscience. Keyword burst detection indicated that neuroinflammation, blood-brain barrier (BBB) and mitochondria dysfunction were the current research hot spots.
Our study revealed that neuroinflammation, blood-brain barrier, and mitochondria dysfunction had been the research foci of SAE over the past 20 years. These have emerged as the basis for transformation from basic research to clinical application in finding effective methods for the prevention and treatment of SAE.
评估脓毒症相关性脑病（SAE）的研究情况，并通过文献计量分析对研究热点进行定量和定性预测。
我们于2021年7月28日从科学网核心合集提取相关出版物。我们使用CiteSpace和VOSviewer软件、文献计量在线分析平台（http://bibliometric.com/）以及Bibliometrix，通过文献计量分析（如共被引分析和聚类分析、关键词共现分析）对检索到的数据进行研究，以分析和预测该领域的趋势和热点。
我们确定了2001年至2021年期间发表的1582篇关于SAE的文章和综述。在此期间，关于SAE的手稿数量稳步增加，并在2021年达到峰值。美国和中国是对SAE研究有重大影响的主要国家。在所有机构中，范德比尔特大学和匹兹堡大学占据领先地位，并成为合作网络的核心。在所有期刊中，有一本期刊在20年内发表了该领域最多的手稿。达尔 - 皮佐尔·费利佩是产出最多的作者（61篇论文），且被引次数最多（930次）。共被引聚类分析显示，以聚类标签形式呈现的关于SAE最热门的术语有危重病、脓毒症相关性脑病、多微生物脓毒症、后部可逆性脑病综合征、大鼠脑、重症监护病房、既往脓毒症、分子氢、炎症驱动、代谢性脑病、谵妄病理生理学和临床神经科学。关键词突现检测表明，神经炎症、血脑屏障（BBB）和线粒体功能障碍是当前的研究热点。
我们的研究表明，在过去20年中，神经炎症、血脑屏障和线粒体功能障碍一直是SAE的研究重点。这些已成为从基础研究向临床应用转变的基础，以寻找预防和治疗SAE的有效方法。
