Huang Kaiyao, Zhu Jianghua, Sun Ke, Wang Heng, Peng Yun, Peng Bibo
Department of Radiology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Intelligent Medical Imaging of Jiangxi Key Laboratory, Nanchang, China.
Medicine (Baltimore). 2025 Jun 13;104(24):e42747. doi: 10.1097/MD.0000000000042747.
Pulmonary embolism (PE) is the third most common cause of cardiovascular death worldwide after stroke and heart attack. Research priorities in each PE period over the past 2 decades remain largely unassessed. This study aims to summarize PE research hotspots and trends using a bibliometric approach and predict future research hotspots. Relevant publications between 2004 and 2023 were extracted from the Web of Science Core Collection. Microsoft Excel 2016 and the R Bibliometrix package were used for descriptive and bibliometric data analyses. Country collaboration was visualized using VOSviewer. CiteSpace was used for the keyword burst analysis and timeline view construction. In total, 25,487 PE-related articles were included in the analysis. The annual number of publications followed a general upward trend. The USA was the most prolific country, with 9568 publications. The timeline of reference indicated 9 clusters including "#1 submassive PE," "#2 suspected PE," "#3 venous thromboembolism," "#4 direct oral anticoagulants," "#5 acute PE," "#6 cancer-associated thrombosis," "#7 medical patient," "#8 PE," and "#9 knee arthroplasty." The keyword "helical computed tomography" had the highest burst strength, followed by "unfractionated heparin," "society" and "molecular weight heparin." The keywords "direct oral anticoagulants," "venous thromboembolism," "american society," "society," "coronavirus disease 2019," "infection," "case report," "pneumonia" and "clinical characteristics" appeared frequently in recent years. Research on PE has focused on risk factor exploration, PE prevention and diagnosis, and then shifted to the treatment strategies, guideline updates, and specific types of PE. The use and feedback of guidelines, better improvement of prognosis, and life quality for PE-specific types might be potential future hotspots.
肺栓塞（PE）是全球范围内仅次于中风和心脏病发作的第三大常见心血管死亡原因。过去20年中每个肺栓塞阶段的研究重点在很大程度上仍未得到评估。本研究旨在采用文献计量学方法总结肺栓塞研究热点和趋势，并预测未来研究热点。从科学网核心合集中提取了2004年至2023年的相关出版物。使用Microsoft Excel 2016和R文献计量学软件包进行描述性和文献计量数据分析。使用VOSviewer可视化国家间合作情况。使用CiteSpace进行关键词突现分析和时间线视图构建。分析共纳入25487篇与肺栓塞相关的文章。出版物数量总体呈上升趋势。美国是发表文章最多的国家，有9568篇出版物。参考文献时间线显示有9个聚类，包括“#1亚大块肺栓塞”“#2疑似肺栓塞”“#3静脉血栓栓塞”“#4直接口服抗凝剂”“#5急性肺栓塞”“#6癌症相关血栓形成”“#7内科患者”“#8肺栓塞”和“#9膝关节置换术”。关键词“螺旋计算机断层扫描”的突现强度最高，其次是“普通肝素”“学会”和“低分子量肝素”。关键词“直接口服抗凝剂”“静脉血栓栓塞”“美国学会”“学会组织”“2019冠状病毒病”“感染”“病例报告”“肺炎”和临床特征”近年来频繁出现。对肺栓塞的研究重点先是危险因素探索、肺栓塞预防和诊断，然后转向治疗策略、指南更新以及特定类型的肺栓塞。指南的使用和反馈、更好地改善预后以及特定类型肺栓塞患者的生活质量可能是未来潜在的研究热点。
