Mao Menghan, Zhou Yanyu, Jiao Yingfu, Yin Suqing, Cheung Chiwai, Yu Weifeng, Gao Po, Yang Liqun
Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Anesthesiology, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Front Med (Lausanne). 2022 Nov 15;9:975376. doi: 10.3389/fmed.2022.975376. eCollection 2022.
The gut microbiota is involved in the regulation of pain, which is proved by plenty of evidence. Although a substantial quantity of research on the link between the gut microbiota and pain has emerged, no study has focused on the bibliometric analysis of this topic. We aim to present a bibliometric review of publications over the past 20 years and predict research hot spots.
Relevant publications between 2002 and 2021 were extracted from the Science Citation Index-Expanded (SCI-EXPANDED) of the Web of Science Core Collection (WoSCC) database on April 22, 2022. CiteSpace (version 5.8 R3c), VOSviewer, the Online Analysis Platform of Literature Metrology, and the R package bibliometrix were used to analyze and visualize.
A total of 233 articles have been published between 2002 and 2021. The number of publication outputs increased rapidly since 2016. The collaboration network revealed that the USA, Baylor College of Medicine, and Vassilia Theodorou were the most influential country, institute, and scholar, respectively. and were the most co-cited journal and was the most productive journal. Visceral sensitivity, fibromyalgia, gastrointestinal, chronic pain, stress, gut microbiome, LGG, brain-gut axis, SLAB51, and sequencing were the top 10 clusters in co-occurrence cluster analysis. Keyword burst detection indicated that the brain-gut axis and short-chain fatty acid were the current research hot spots.
Research on the links between the gut microbiota and pain has increased rapidly since 2016. The current research focused on the brain-gut axis and short-chain fatty acid. Accordingly, the SCFAs-mediated mechanism of pain regulation will be a research direction of great importance on the links between the gut microbiota and pain. This study provided instructive assistance to direct future research efforts on the links between the gut microbiota and pain.
大量证据表明，肠道微生物群参与疼痛调节。尽管已经出现了大量关于肠道微生物群与疼痛之间联系的研究，但尚无研究聚焦于该主题的文献计量分析。我们旨在对过去20年的相关出版物进行文献计量综述，并预测研究热点。
2022年4月22日，从Web of Science核心合集（WoSCC）数据库的科学引文索引扩展版（SCI-EXPANDED）中提取2002年至2021年的相关出版物。使用CiteSpace（5.8 R3c版）、VOSviewer、文献计量在线分析平台和R包bibliometrix进行分析和可视化。
2002年至2021年共发表了233篇文章。自2016年以来，发表产出数量迅速增加。合作网络显示，美国、贝勒医学院和瓦西利亚·西奥多罗分别是最具影响力的国家、机构和学者。《 》和《 》是被引频次最高的期刊，《 》是发文量最高的期刊。内脏敏感性、纤维肌痛、胃肠道、慢性疼痛、应激、肠道微生物群、鼠李糖乳杆菌、脑-肠轴、SLAB51和测序是共现聚类分析中的前10个聚类。关键词突现检测表明，脑-肠轴和短链脂肪酸是当前的研究热点。
自2016年以来，肠道微生物群与疼痛之间联系的研究迅速增加。当前的研究集中在脑-肠轴和短链脂肪酸。因此，短链脂肪酸介导的疼痛调节机制将是肠道微生物群与疼痛之间联系的一个非常重要的研究方向。本研究为指导未来关于肠道微生物群与疼痛之间联系的研究工作提供了有益的帮助。
