Institute of Allergy and Immunology, Health Science Center, Shenzhen University, Shenzhen, 518060, People's Republic of China.
Mol Biol Rep. 2020 Aug;47(8):6239-6246. doi: 10.1007/s11033-020-05613-1. Epub 2020 Aug 14.
Dust mites are an important cause of allergic diseases worldwide. The traces of Dermatophagoides farinae and Dermatophagoides pteronyssinus can be found all over the world, while Blomia tropicalis are more common allergenic mites in tropical areas. A variety of allergenic components in dust mites have been found, apart from the different positive rates of IgE reactions in dust mite allergic patients, their biological characteristics, effects on the innate immune system, and especially their distribution characteristics in patients are different. Studying the relationship between dust mite allergens and clinical significance will help for diagnosis of patients and formulation of corresponding Allergen Specific Immunotherapy.
尘螨是全世界范围内引起过敏疾病的重要原因。全世界都能发现屋尘螨和粉尘螨的踪迹，而热带地区则更常见过敏原性螨类——孳尘螨。尘螨中已发现多种过敏原成分，除了尘螨过敏患者 IgE 反应的阳性率不同外，它们的生物学特性、对固有免疫系统的影响，特别是在患者中的分布特点也不同。研究尘螨过敏原与临床意义的关系有助于对患者的诊断和制定相应的变应原特异性免疫治疗方案。
