Department of Gerontology, Neuroscience and Orthopedics, Fondazione Universitaria Policlinico Gemelli, IRCCS, Rome, Italy.
Unità Operativa Complessa Di Neurologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
BMC Neurol. 2022 Mar 16;22(1):96. doi: 10.1186/s12883-022-02622-4.
Neurological manifestations of Sars-CoV-2 infection have been described since March 2020 and include both central and peripheral nervous system manifestations. Neurological symptoms, such as headache or persistent loss of smell and taste, have also been documented in COVID-19 long-haulers. Moreover, long lasting fatigue, mild cognitive impairment and sleep disorders appear to be frequent long term neurological manifestations after hospitalization due to COVID-19. Less is known in relation to peripheral nerve injury related to Sars-CoV-2 infection.
We report the case of a 47-year-old female presenting with a unilateral chest pain radiating to the left arm lasting for more than two months after recovery from Sars-CoV-2 infection. After referral to our post-acute outpatient service for COVID-19 long haulers, she was diagnosed with a unilateral, atypical, pure sensory brachial plexus neuritis potentially related to COVID-19, which occurred during the acute phase of a mild Sars-CoV-2 infection and persisted for months after resolution of the infection.
We presented a case of atypical Parsonage-Turner syndrome potentially triggered by Sars-CoV-2 infection, with symptoms and repercussion lasting after viral clearance. A direct involvement of the virus remains uncertain, and the physiopathology is unclear. The treatment of COVID-19 and its long-term consequences represents a relatively new challenge for clinicians and health care providers. A multidisciplinary approach to following-up COVID-19 survivors is strongly advised.
自 2020 年 3 月以来，已经描述了 Sars-CoV-2 感染的神经表现，包括中枢和外周神经系统表现。COVID-19 长程患者也记录了头痛或持续嗅觉和味觉丧失等神经症状。此外，由于 COVID-19 住院后，持久疲劳、轻度认知障碍和睡眠障碍似乎是常见的长期神经表现。与 Sars-CoV-2 感染相关的周围神经损伤知之甚少。
我们报告了一例 47 岁女性的病例，该女性在 Sars-CoV-2 感染康复后两个月以上出现单侧胸痛，向左臂放射。在因 COVID-19 长程患者转诊至我们的急性后门诊服务后，她被诊断为单侧、非典型、单纯感觉性臂丛神经炎，可能与 COVID-19 有关，该神经炎发生在轻度 Sars-CoV-2 感染的急性期，在感染消退后持续数月。
我们提出了一例可能由 Sars-CoV-2 感染引发的非典型帕森斯-特纳综合征病例，其症状和影响在病毒清除后持续存在。病毒的直接参与尚不确定，病理生理学尚不清楚。治疗 COVID-19 及其长期后果是临床医生和医疗保健提供者面临的相对较新的挑战。强烈建议对 COVID-19 幸存者进行多学科随访。
