在荷兰，兽医医护人员粪便携带率较低。
Faecal carriage of is low among veterinary healthcare workers in the Netherlands.
机构信息
Centre for Infectious Disease Control (CIb), National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands.
出版信息
Epidemiol Infect. 2022 Feb 28;150:e63. doi: 10.1017/S0950268822000383.
Veterinary healthcare workers are in close contact with many different animals and might be at an increased risk of acquiring Clostridioides difficile. In this cross-sectional study, we assessed the prevalence and risk factors of C. difficile carriage in Dutch veterinary healthcare workers. Participants provided a faecal sample and filled out a questionnaire covering potential risk factors for C. difficile carriage. C. difficile culture positive isolates were polymerase chain reaction (PCR) ribotyped and the presence of toxin genes tcdA, tcdB and cdtA/cdtB was determined. Eleven of 482 [2.3%; 95% confidence interval (CI) 1.3-4.0] veterinary healthcare workers were carriers of C. difficile. Three persons carried C. difficile ribotype 078 (0.6%; 95% CI 0.2-1.8). Risk factors for carriage were health/medication and hygiene related, including poor hand hygiene after patient (animal) contact, and did not include occupational contact with certain animal species. In conclusion, the prevalence of C. difficile carriage in veterinary healthcare workers was low and no indications were found that working in veterinary care is a risk for C. difficile carriage.
兽医保健工作者与许多不同的动物密切接触，因此他们可能面临更高的艰难梭菌感染风险。在这项横断面研究中，我们评估了荷兰兽医保健工作者艰难梭菌携带的流行率和危险因素。参与者提供了粪便样本，并填写了一份问卷，其中包括艰难梭菌携带的潜在危险因素。对艰难梭菌培养阳性的分离株进行聚合酶链反应（PCR）核糖体分型，并确定毒素基因 tcdA、tcdB 和 cdtA/cdtB 的存在。482 名兽医保健工作者中有 11 名（2.3%；95%置信区间 [CI] 1.3-4.0）为艰难梭菌携带者。3 人携带艰难梭菌 078 型（0.6%；95% CI 0.2-1.8）。携带的危险因素与健康/药物和卫生有关，包括接触病人（动物）后手部卫生较差，并且不包括与某些动物种类的职业接触。总之，兽医保健工作者中艰难梭菌携带的流行率较低，没有迹象表明在兽医护理工作中接触艰难梭菌会增加其携带风险。
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