Institute of Pharmaceutical Research, GLA University, Mathura, U.P., India.
Department of Pharmacology, School of Health Sciences, Central University of Punjab, Bathinda- 151001, Punjab, India.
Curr Drug Targets. 2022;23(9):889-901. doi: 10.2174/1389450123666220316091734.
Parkinson's disease is a chronic and gradually progressive neurodegenerative disorder triggered due to the loss of dopamine-releasing neurons in the region of substantia nigra pars compacta characterized by the motor symptoms, such as tremor, bradykinesia, akinesia, and postural instability. Proteinopathies, mitochondrial dysfunction induced dopaminergic neuronal deterioration, and gene mutations are the hallmarks of Parkinson's disease. The bioactive components of Brahmi, such as Bacoside A, Bacoside B, and Bacosaponins, belong to various chemical families. Brahmi's neuroprotective role includes reducing neuronal oxidative stress, dopaminergic neuronal degeneration, mitochondrial dysfunction, inflammation, inhibition of α-synuclein aggregation, and improvement of cognitive and learning behaviour. Researchers found that Bacopa monnieri significantly increased brain levels of glutathione, vitamin C, vitamin E, and vitamin A in rats exposed to cigarette smoke. Brahmi has a potent antioxidant property and neuroprotective effects against PD that help reduce oxidative stress and neuroinflammation and enhance dopamine levels. The review collates all the preclinical studies that prove the beneficial neuroprotective effect of Brahmi for treating PD.
帕金森病是一种慢性、进行性神经退行性疾病，由黑质致密部多巴胺能神经元缺失引起，其特征为运动症状，如震颤、运动迟缓、运动不能和姿势不稳。蛋白病、线粒体功能障碍导致多巴胺能神经元恶化以及基因突变是帕金森病的标志。Brahmi 的生物活性成分，如 Bacoside A、Bacoside B 和 Bacosaponins，属于不同的化学家族。Brahmi 的神经保护作用包括减少神经元氧化应激、多巴胺能神经元变性、线粒体功能障碍、炎症、抑制α-突触核蛋白聚集以及改善认知和学习行为。研究人员发现，在暴露于香烟烟雾的大鼠中，Bacopa monnieri 显著增加了大脑中谷胱甘肽、维生素 C、维生素 E 和维生素 A 的水平。Brahmi 具有强大的抗氧化和神经保护作用，可减轻氧化应激和神经炎症，提高多巴胺水平。本综述收集了所有证明 Brahmi 对治疗 PD 具有有益的神经保护作用的临床前研究。
