Department of Biochemistry, King George's Medical University (KGMU), Lucknow, UP, 226003, India.
Era University, Lucknow, UP, India.
Metab Brain Dis. 2020 Mar;35(3):517-525. doi: 10.1007/s11011-019-00526-w. Epub 2019 Dec 13.
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by loss of dopaminergic neurons in substantia nigra region and the presence of α-synuclein aggregates in the striatum and surrounding areas of brain. Evidences suggest that neuroinflammation plays a role in the progression of PD. We examined the neuro-protective effects of Bacopa monnieri (BM) in regulating neuroinflammation. Administration of BM suppressed the level of pro-inflammatory cytokines, decreased the levels of α-synuclein, and reduced reactive oxygen species (ROS) generation in PD animal model. Pre-treatment of BM showed more prominent results as compare to co- and post-treatment. Results suggest that Bacopa can limit inflammation in the different areas of brain, thus, offers a promising source of novel therapeutics for the treatment of many CNS disorders.
帕金森病（PD）是一种常见的神经退行性疾病，其特征是黑质区域多巴胺能神经元丧失，纹状体和大脑周围区域存在α-突触核蛋白聚集。有证据表明，神经炎症在 PD 的进展中起作用。我们研究了假马齿苋（BM）在调节神经炎症方面的神经保护作用。BM 的给药抑制了促炎细胞因子的水平，降低了α-突触核蛋白的水平，并减少了 PD 动物模型中的活性氧（ROS）生成。与同时和后续治疗相比，BM 的预处理显示出更显著的效果。结果表明，假马齿苋可以限制大脑不同区域的炎症，因此为治疗许多中枢神经系统疾病提供了有希望的新治疗方法来源。
