Kushner R F, Schoeller D A
Am J Clin Nutr. 1986 Sep;44(3):417-24. doi: 10.1093/ajcn/44.3.417.
Total body water (TBW) measured by bioelectrical impedance analysis (BIA) was directly compared with deuterium-isotope dilution in a total of 58 subjects. First, sex-specific and group equations were developed by multiple regression analysis in (10 each) obese and nonobese men and women. Height/resistive impedance was the most significant variable used to predict deuterium-dilution space (D2O-TBW) and, combined with weight, yielded R = 0.99 and SE of estimate = 1.75 L. Equations predicted D2O-TBW equally well for obese and nonobese subjects. Second, the equations were prospectively tested in a heterogeneous group of 6 males and 12 females. Sex-specific equations predicted D2O-TBW with good correlation coefficients (0.96 and 0.93), total error (2.34 and 2.89 L), and a small difference between mean predicted and measured D2O-TBW (-1.4 +/- 2.05 and -0.48 +/- 2.83 L). BIA predicts D2O-TBW more accurately than weight, height, and/or age. A larger population is required to validate the applicability of our equations.
通过生物电阻抗分析（BIA）测量的总体水（TBW）与氘同位素稀释法在总共58名受试者中进行了直接比较。首先，通过多元回归分析在（各10名）肥胖和非肥胖男性及女性中建立了性别特异性和分组方程。身高/电阻抗是用于预测氘稀释空间（D2O-TBW）的最显著变量，与体重相结合，得到R = 0.99，估计标准误（SE）= 1.75 L。该方程对肥胖和非肥胖受试者预测D2O-TBW的效果同样良好。其次，在一组由6名男性和12名女性组成的异质性群体中对这些方程进行了前瞻性测试。性别特异性方程预测D2O-TBW具有良好的相关系数（分别为0.96和0.93）、总误差（分别为2.34和2.89 L），并且预测的D2O-TBW均值与测量值之间的差异较小（分别为-1.4±2.05和-0.48±2.83 L）。BIA预测D2O-TBW比体重、身高和/或年龄更准确。需要更大规模的人群来验证我们方程的适用性。
