Stein H, Hansmann M L, Lennert K, Brandtzaeg P, Gatter K C, Mason D Y
Am J Clin Pathol. 1986 Sep;86(3):292-7. doi: 10.1093/ajcp/86.3.292.
To throw light on the question of whether B-cell-derived forms of Hodgkin's disease exist, more than 100 cases of Hodgkin's disease (including all four major histologic categories) were investigated for the presence of J chain and were also immunostained for epithelial membrane antigen and the granulocyte-associated antigen X hapten. Reed-Sternberg and Hodgkin cells (RS & H) expressed J chain in 22 cases, 8 of which also expressed epithelial membrane antigen (EMA). X hapten was found in 62 cases, but all of these were J chain negative. J chain-positive RS & H cells were restricted to cases of lymphocyte-predominant disease, while X hapten-positive tumor cells were found frequently in nodular sclerosis, mixed cellularity, and lymphocyte-depletion Hodgkin's disease, but only occasionally in cases of lymphocyte-predominant disease. These findings indicate that nodular lymphocyte-predominant Hodgkin's disease differs from the other subtypes of Hodgkin's disease and that the neoplastic cells are of B-lymphoid origin.
为了阐明霍奇金淋巴瘤是否存在B细胞来源的类型，我们对100多例霍奇金淋巴瘤（包括所有四种主要组织学类型）进行了研究，检测其中J链的存在情况，并进行上皮膜抗原和粒细胞相关抗原X半抗原的免疫染色。在22例病例中，里德-斯腾伯格细胞和霍奇金细胞（RS&H）表达J链，其中8例还表达上皮膜抗原（EMA）。62例病例中发现了X半抗原，但所有这些病例的J链均为阴性。J链阳性的RS&H细胞仅限于淋巴细胞为主型疾病，而X半抗原阳性的肿瘤细胞在结节硬化型、混合细胞型和淋巴细胞消减型霍奇金淋巴瘤中较为常见，但在淋巴细胞为主型疾病中仅偶尔出现。这些发现表明，结节性淋巴细胞为主型霍奇金淋巴瘤与霍奇金淋巴瘤的其他亚型不同，其肿瘤细胞起源于B淋巴细胞。
