将第三个嘌呤生物合成基因（甘氨酰胺核糖核苷酸转甲酰基酶）定位于人类21号染色体。
Assignment of a third purine biosynthetic gene (glycinamide ribonucleotide transformylase) to human chromosome 21.
作者信息
Hards R G, Benkovic S J, Van Keuren M L, Graw S L, Drabkin H A, Patterson D
出版信息
Am J Hum Genet. 1986 Aug;39(2):179-85.
Abstract
Using a series of human-hamster hybrid cell lines, a gene coding for glycinamide ribonucleotide transformylase was mapped to human chromosome 21. The availability of hybrids containing only portions of chromosome 21 allowed the gene to be assigned to the region between the q11.2 and the q22.2 bands, inclusive. Differentiation of human and hamster glycinamide ribonucleotide transformylase was accomplished via an immunoprecipitation assay that employed a polyclonal antibody raised against the human enzyme.
摘要
利用一系列人-仓鼠杂交细胞系，将编码甘氨酰胺核糖核苷酸转甲酰基酶的基因定位到人类21号染色体上。仅包含21号染色体部分片段的杂交细胞系，使得该基因被定位到q11.2和q22.2带之间的区域（包括这两个带）。通过使用针对人源酶产生的多克隆抗体的免疫沉淀试验，实现了人和仓鼠甘氨酰胺核糖核苷酸转甲酰基酶的区分。
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