Veronin Michael A
Social and Administrative Sciences, Department of Pharmaceutical Sciences and Health Outcomes, The University of Texas at Tyler, Ben and Maytee Fisch College of Pharmacy, Tyler, TX, 75799, USA.
Drug Healthc Patient Saf. 2022 Mar 10;14:19-26. doi: 10.2147/DHPS.S332954. eCollection 2022.
A commonly reported definition of polypharmacy is the numerical definition of 5 or more medications daily, and definitions have ranged from 2 or more to 11 or more medications. In this case report, an extreme case of polypharmacy is presented, highlighted by the inordinate number of drugs used over time throughout the patient's care. A 48-year-old African American female with multiple comorbidities experienced a serious adverse drug event (ADE) prompting reporting to MedWatch, the US Food and Drug Administration's adverse drug event reporting system. The patient's concomitant medications included 146 drug entities, across 82 therapeutic drug categories. It is apparent that the greatest influence on the occurrence of polypharmacy was the presence of multiple comorbidities, and treatment centered around addressing each morbidity with drug therapy. This case illustrates the insidious nature of polypharmacy and raises questions as to the appropriate progression and limits on the use of multiple medications.
多重用药的一个常见定义是每日服用5种或更多药物的数值定义，其定义范围从2种或更多到11种或更多药物不等。在本病例报告中，呈现了一个多重用药的极端案例，其突出特点是在患者整个治疗过程中随着时间推移使用了过多数量的药物。一名患有多种合并症的48岁非裔美国女性经历了严重的药物不良事件（ADE），促使其向美国食品药品监督管理局的不良药物事件报告系统MedWatch报告。该患者的合并用药包括146种药物实体，分属82个治疗药物类别。显然，对多重用药发生影响最大的是多种合并症的存在，并且治疗围绕使用药物疗法应对每种病症展开。本病例说明了多重用药的潜在危害，并引发了关于多种药物使用的适当进程和限制的问题。
