Reindollar R H, Novak M, Tho S P, McDonough P G
Am J Obstet Gynecol. 1986 Sep;155(3):531-43. doi: 10.1016/0002-9378(86)90274-7.
A series of 262 patients with amenorrhea of adult onset are reported. Hypothalamic suppression followed by inappropriate positive feedback, and then hyperprolactinemia and ovarian failure are the most frequently encountered etiologies. Other etiologies are diverse and numerically less frequent. Amenorrhea after use of oral contraceptives, or postpill amenorrhea, occurred in 77 (29%) of all patients. The average age of presentation, prior menstrual history, associated morbidity, and subsequent reproductive potential of each diagnostic group are reported. Adult-onset amenorrhea has a less significant impact on future wellbeing than was reported for a similar-sized group of patients whose amenorrhea developed as a result of pubertal aberrancy.
报告了一系列262例成年期发病的闭经患者。下丘脑抑制随后出现不适当的正反馈，然后是高催乳素血症和卵巢功能衰竭是最常见的病因。其他病因多种多样且数量较少见。在所有患者中，77例（29%）出现口服避孕药后闭经或停药后闭经。报告了每个诊断组的平均就诊年龄、既往月经史、相关发病率以及随后的生殖潜能。与因青春期异常而闭经的类似规模患者组相比，成年期发病的闭经对未来健康的影响较小。
