Mörö Sara, Kosola Silja, Holopainen Elina
Children's Hospital and Pediatric Research Center, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.
Research, Development and Innovations, Western Uusimaa Wellbeing Services County, Espoo, Finland.
Front Public Health. 2024 Feb 16;12:1304277. doi: 10.3389/fpubh.2024.1304277. eCollection 2024.
Among adolescents, amenorrhea is a common reason for medical consultation. Despite the variety of underlying etiologies, the prevalence of the causes is incompletely understood. This study aimed to assess the demographic and etiological factors among patients with amenorrhea treated in a single specialist unit of adolescent gynecology.
Retrospective register study.
Medical records of 438 girls evaluated for primary or secondary amenorrhea in a single tertiary care center between 2015 and 2019 were retrospectively reviewed. In all, 423 patients-171 with primary amenorrhea and 252 with secondary amenorrhea-were included in the study. Data on underlying conditions, anthropometric variables, and selected hormonal markers were analyzed.
Functional hypogonadotropic hypogonadism was the most frequent reason for primary (56%) and secondary (78%) amenorrhea. It was mostly explained by lifestyle-related functional hypothalamic amenorrhea caused by disordered eating, intense exercise, energy deficiency, psychological stress, and their combinations.
Menstrual pattern is a significant indicator of overall health and well-being among adolescent girls and young women. Functional reasons behind primary and secondary amenorrhea are important to recognize. Treatment often requires long-term lifestyle modifications. The frequency of functional causes also implies that most amenorrhea cases are preventable.
在青少年中，闭经是就医的常见原因。尽管潜在病因多种多样，但病因的患病率尚未完全明确。本研究旨在评估在青少年妇科单一专科单位接受治疗的闭经患者的人口统计学和病因学因素。
回顾性登记研究。
回顾性分析了2015年至2019年间在单一三级医疗中心对438名女孩进行原发性或继发性闭经评估的病历。本研究共纳入423例患者，其中171例原发性闭经患者和252例继发性闭经患者。分析了潜在疾病、人体测量变量和选定的激素标志物的数据。
功能性低促性腺激素性性腺功能减退是原发性闭经（56%）和继发性闭经（78%）最常见的原因。其主要原因是由饮食紊乱、剧烈运动、能量缺乏、心理压力及其组合导致的与生活方式相关的功能性下丘脑性闭经。
月经模式是青少年女孩和年轻女性整体健康和幸福的重要指标。认识原发性和继发性闭经背后的功能性原因很重要。治疗通常需要长期改变生活方式。功能性原因的频率也意味着大多数闭经病例是可以预防的。
