Su Zheng, Jia Xin-Hua, Zhao Fang-Hui, Zhou Qing-Hua, Fan Ya-Guang, Qiao You-Lin
Department of Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, China.
Front Oncol. 2022 Mar 1;12:817045. doi: 10.3389/fonc.2022.817045. eCollection 2022.
This special cohort reveals the effect of smoking cessation in occupational miners exposed to radon and arsenic.
A total of 9,134 tin miners with at least 10 years of underground radon and arsenic exposure were enrolled beginning in 1992 and followed for up to 27 years. Detailed smoking information was collected at baseline, and information on smoking status was consecutively collected from 1992 to 1996. The Cox proportional hazards model was used to explore the relationship between time since smoking cessation and lung cancer.
A total of 1,324 lung cancer cases occurred in this cohort over 167,776 person-years of follow-up. Among populations exposed to radon and arsenic, miners after quitting smoking for 10 years or more had almost halved their lung cancer risk [adjusted hazard ratio (HR) = 0.55, 95% CI: 0.38-0.79], compared with current smokers. Among miners after quitting smoking for 5 years or more, lung cancer incidence approximately halved (HR = 0.52, 95% CI: 0.30-0.92) for squamous cell lung carcinoma, while it showed no significant decline for adenocarcinoma (HR = 0.79, 95% CI: 0.34-1.85).
Smoking cessation for 10 years or more halved lung cancer incidence among miners exposed to radon and arsenic, and the benefit was more pronounced among squamous cell lung carcinoma.
该特殊队列揭示了氡和砷暴露的职业矿工戒烟的效果。
从1992年开始，共纳入9134名至少有10年地下氡和砷暴露史的锡矿矿工，并随访长达27年。在基线时收集详细的吸烟信息，并在1992年至1996年连续收集吸烟状况信息。采用Cox比例风险模型探讨戒烟时间与肺癌之间的关系。
在167776人年的随访中，该队列共发生1324例肺癌病例。在暴露于氡和砷的人群中，与当前吸烟者相比，戒烟10年或更长时间的矿工患肺癌的风险几乎减半[调整后风险比（HR）=0.55，95%可信区间：0.38-0.79]。在戒烟5年或更长时间的矿工中，鳞状细胞肺癌的发病率约减半（HR=0.52，95%可信区间：0.30-0.92），而腺癌发病率无显著下降（HR=0.79，95%可信区间：0.34-1.85）。
戒烟10年或更长时间可使氡和砷暴露矿工的肺癌发病率减半，且鳞状细胞肺癌的获益更为明显。
