Faiha Specialized Diabetes, Endocrine and Metabolism Center, Basrah Health Directorate, Alzahraa College of Medicine, Basrah, Iraq.
College of Medicine, University of Basrah, Basrah, Iraq.
Sultan Qaboos Univ Med J. 2022 Feb;22(1):123-128. doi: 10.18295/squmj.5.2021.084. Epub 2022 Feb 28.
This study aimed to evaluate whether a shorter fasting duration of five to six hours can be used as an alternative to the usually recommended eight hours for fasting glucose measurement.
This one-month observational, cross-sectional study was conducted during Ramadan (May to June) 2019. It included those attending Faiha Specialized Diabetes, Endocrine and Metabolism Center, Basrah, Iraq; all individuals ate a pre-dawn meal (suhoor) followed by a complete fast for many hours. Two fasting serum glucose (FSG) venous samples were taken; the first was taken five to six hours and the second eight hours after the pre-dawn meal. Participants were divided into two groups: individuals with type 2 diabetes mellitus (T2DM) and those with a normal glucose level. T2DM patients were further subdivided into three groups: those without treatment, those on oral antidiabetic drugs (OAD) and those using insulin and OAD.
A total of 200 individuals participated in this study. There was no significant difference found between the mean FSG levels in the first and second samples for those without T2DM (104.5 ± 21.4 mg/dL versus 104.8 ± 12.6 mg/dL; = 0.80) as well as those with T2DM (235.0 ± 107.0 mg/dL versus 230.0 ± 105.0 mg/dL; = 0.20). Untreated T2DM patients had non-significant FSG readings for the two samples (194.0 ± 151.5 mg/dL versus 193.9 ± 128.9 mg/dL; = 0.90). Patients on insulin and OAD showed a similar pattern of FSG (268.0 ± 111.0 mg/dL versus 269.0 ± 114.0 mg/dL). However, the two FSG samples were found to be significantly different among patients on OAD (220.0 ± 78.0 mg/dL versus 207.0 ± 77.0 mg/dL; = 0.01).
The fasting duration of five to six hours can give a comparable measurement of FSG as that obtained after eight hours.
本研究旨在评估禁食 5 至 6 小时是否可以替代通常建议的禁食 8 小时来测量空腹血糖。
这是一项为期一个月的观察性、横断面研究，于 2019 年斋月（5 月至 6 月）期间在伊拉克巴士拉的 Faiha 专业糖尿病、内分泌和代谢中心进行。所有参与者均在黎明前（苏胡尔）进食，然后禁食数小时。采集了两份空腹血清葡萄糖（FSG）静脉样本；第一份在黎明前用餐后 5 至 6 小时采集，第二份在 8 小时后采集。参与者分为两组：2 型糖尿病患者（T2DM）和血糖正常者。T2DM 患者进一步分为三组：未治疗者、服用口服降糖药（OAD）者和使用胰岛素和 OAD 者。
共有 200 人参加了这项研究。在无 T2DM 患者（104.5 ± 21.4 mg/dL 与 104.8 ± 12.6 mg/dL； = 0.80）和 T2DM 患者（235.0 ± 107.0 mg/dL 与 230.0 ± 105.0 mg/dL； = 0.20）中，第二份样本的 FSG 水平与第一份样本相比没有显著差异。未治疗的 T2DM 患者的两份样本 FSG 读数无显著差异（194.0 ± 151.5 mg/dL 与 193.9 ± 128.9 mg/dL； = 0.90）。使用胰岛素和 OAD 的患者 FSG 模式相似（268.0 ± 111.0 mg/dL 与 269.0 ± 114.0 mg/dL）。然而，OAD 患者的两份 FSG 样本之间存在显著差异（220.0 ± 78.0 mg/dL 与 207.0 ± 77.0 mg/dL； = 0.01）。
禁食 5 至 6 小时可以获得与禁食 8 小时相当的 FSG 测量值。
