Adult Stem Cell Laboratory, The Francis Crick Institute, London, UK; Cancer Stem Cell Laboratory, The Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, London, UK.
Department of Molecular Pathology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Trends Cancer. 2022 Jun;8(6):494-505. doi: 10.1016/j.trecan.2022.02.007. Epub 2022 Mar 15.
The 3D architecture of tissues bearing tumors impacts on the mechanical microenvironment of cancer, the accessibility of stromal cells, and the routes of invasion. A myriad of intrinsic and extrinsic forces exerted by the cancer cells, the host tissue, and the molecular and cellular microenvironment modulate the morphology of the tumor and its malignant potential through mechanical, biochemical, genetic, and epigenetic cues. Recent studies have investigated how tissue architecture influences cancer biology from tumor initiation and progression to distant metastatic seeding and response to therapy. With a focus on carcinoma, the most common type of cancer, this review discusses the latest discoveries on how tumor architecture is built and how tissue morphology affects the biology and progression of cancer cells.
肿瘤组织的三维结构影响癌症的机械微环境、基质细胞的可及性以及侵袭途径。癌细胞、宿主组织以及分子和细胞微环境施加的无数内在和外在力通过机械、生化、遗传和表观遗传线索调节肿瘤的形态及其恶性潜能。最近的研究调查了组织架构如何影响癌症生物学，从肿瘤起始和进展到远处转移播种以及对治疗的反应。本文以最常见的癌症类型——癌为重点，讨论了肿瘤结构的最新发现以及组织形态如何影响癌细胞的生物学和进展。
