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The TARGET trial as a plea for model-informed precision dosing of piperacillin/tazobactam in patients with sepsis.

作者信息

Gijsen Matthias, Dreesen Erwin, Wauters Joost, Debaveye Yves, Spriet Isabel

机构信息

Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium.

Pharmacy Department, University Hospitals Leuven, Leuven, Belgium.

出版信息

Intensive Care Med. 2022 Jun;48(6):768-769. doi: 10.1007/s00134-022-06679-0. Epub 2022 Mar 17.

DOI:10.1007/s00134-022-06679-0
PMID:35301548
Abstract
摘要

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The TARGET trial as a plea for model-informed precision dosing of piperacillin/tazobactam in patients with sepsis.TARGET试验呼吁对脓毒症患者进行基于模型的哌拉西林/他唑巴坦精准给药。
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引用本文的文献

1
Towards model-informed precision dosing of piperacillin: multicenter systematic external evaluation of pharmacokinetic models in critically ill adults with a focus on Bayesian forecasting.朝向哌拉西林的模型指导下精准给药:以贝叶斯预测为重点,对危重症成年患者的药代动力学模型进行多中心系统外部评估。
Intensive Care Med. 2023 Aug;49(8):966-976. doi: 10.1007/s00134-023-07154-0. Epub 2023 Jul 13.
2
Dose optimization of β-lactams antibiotics in pediatrics and adults: A systematic review.儿童和成人β-内酰胺类抗生素的剂量优化:一项系统评价。
Front Pharmacol. 2022 Sep 21;13:964005. doi: 10.3389/fphar.2022.964005. eCollection 2022.