Tintó-Font Elisabet, Cortés Alfred
ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona 08036, Catalonia, Spain.
ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona 08036, Catalonia, Spain; ICREA, Barcelona 08010, Catalonia, Spain.
Trends Parasitol. 2022 Jun;38(6):435-449. doi: 10.1016/j.pt.2022.02.009. Epub 2022 Mar 15.
The capacity of malaria parasites to respond to changes in their environment at the transcriptional level has been the subject of debate, but recent evidence has unambiguously demonstrated that Plasmodium spp. can produce adaptive transcriptional responses when exposed to some specific types of stress. These include metabolic conditions and febrile temperature. The Plasmodium falciparum protective response to thermal stress is similar to the response in other organisms, but it is regulated by a transcription factor evolutionarily unrelated to the conserved transcription factor that drives the heat shock (HS) response in most eukaryotes. Of the many genes that change expression during HS, only a subset constitutes an authentic response that contributes to parasite survival.
疟原虫在转录水平上对环境变化作出反应的能力一直是争论的焦点，但最近的证据明确表明，疟原虫属在暴露于某些特定类型的应激时能够产生适应性转录反应。这些应激包括代谢条件和发热温度。恶性疟原虫对热应激的保护反应与其他生物体中的反应相似，但它是由一种转录因子调控的，该转录因子在进化上与驱动大多数真核生物热休克（HS）反应的保守转录因子无关。在热休克期间表达发生变化的众多基因中，只有一部分构成有助于寄生虫存活的真正反应。
