U.O.C. Radioterapia Oncologica, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Eur Rev Med Pharmacol Sci. 2022 Mar;26(5):1695-1700. doi: 10.26355/eurrev_202203_28238.
Eccrine porocarcinoma (EPC) is a malignant adnexal tumor accounting for about 0.005% of skin tumors. The standard treatment of EPC is the complete surgical excision of the primary lesion and of the clinically involved lymph nodes. There is limited evidence regarding the role of radiotherapy (RT) in managing EPC after surgery. Therefore, the aim of this multidisciplinary systematic review is to analyze the available evidence about postoperative RT in the curative treatment of EPC.
A systematic search strategy was launched trough the main scientific databases including PubMed, Scopus and Cochrane. An additional manual search and a chain citation were performed about potentially relevant papers. The key words used for the search included "eccrine porocarcinoma", "porocarcinoma", "radiotherapy", "radiation therapy", "adjuvant radiotherapy" and "postoperative radiotherapy".
A total of 104 publications were identified and 14 papers were included in the final analysis. The only articles found on adjuvant RT in EPC were case reports published between 1996 and 2019. There was a slight female prevalence (57% female/43% male) with a mean age of 65 years (range 37-85). Head-and-neck region was the most frequently involved anatomical site followed by legs.
Adjuvant radiotherapy after surgical removal of EPC could be considered in cases with positive or close margins and in cases with unfavorable histological features. In view of limited literature data and the rarity of EPC the best treatment sequence should always be discussed within the frame of a multidisciplinary setting.
adjuvant radiotherapy after surgical removal of EPC could be considered in cases with positive or close margins and in cases with unfavorable histological features.
汗管癌（EPC）是一种恶性附属器肿瘤，约占皮肤肿瘤的 0.005%。EPC 的标准治疗方法是完全切除原发性病变和临床受累的淋巴结。关于手术后放疗（RT）在 EPC 治疗中的作用，证据有限。因此，本多学科系统评价的目的是分析关于手术后 RT 在 EPC 治愈性治疗中的可用证据。
通过包括 PubMed、Scopus 和 Cochrane 在内的主要科学数据库启动了系统搜索策略。对潜在相关论文进行了额外的手动搜索和连锁引文。搜索中使用的关键词包括“汗管癌”、“porocarcinoma”、“放疗”、“放射治疗”、“辅助放疗”和“术后放疗”。
共确定了 104 篇出版物，最终分析中纳入了 14 篇论文。唯一发现的关于 EPC 辅助 RT 的文章是 1996 年至 2019 年期间发表的病例报告。女性略占优势（57%女性/43%男性），平均年龄为 65 岁（范围 37-85 岁）。头颈部是最常受累的解剖部位，其次是腿部。
对于切缘阳性或接近切缘以及具有不利组织学特征的病例，可考虑在手术切除 EPC 后进行辅助放疗。鉴于有限的文献数据和 EPC 的罕见性，最佳治疗顺序应始终在多学科框架内进行讨论。
对于切缘阳性或接近切缘以及具有不利组织学特征的病例，可考虑在手术切除 EPC 后进行辅助放疗。
