College of Medicine, The Ohio State University, Columbus, Ohio, USA.
Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.
AIDS Res Hum Retroviruses. 2022 Jul;38(7):544-551. doi: 10.1089/AID.2021.0154. Epub 2022 Apr 21.
Age-related comorbidities and physical function impairments in aging people with HIV (PWH) can be improved through exercise interventions. The mechanisms underlying these improvements, including lipidomic changes, are unknown. Sedentary adults (50-75 years old) with or without HIV participated in supervised endurance/resistance exercise for 24 weeks. Plasma lipid concentrations (∼1,200 lipid species from 13 lipid classes) at baseline and week 24 were measured by mass spectrometry. Given multiple comparisons, unadjusted and Benjamini-Hochberg corrected values are reported. Analyses are considered exploratory. Twenty-five PWH and 24 controls had paired samples at baseline and week 24. The change in total triacylglycerol (TAG) concentrations after exercise intervention differed between groups (unadj- = 0.006, adj- = 0.078) with concentrations increasing among controls, but not among PWH. Changes in concentrations of TAG species composed of long-chain fatty acids differed between groups (unadj- < 0.04) with increases among controls, but not among PWH. Changes in total diacylglycerol (DAG) concentration from baseline to week 24 differed between groups (unadj- = 0.03, adj- = 0.2) with an increase in PWH and a nonsignificant decrease in controls. Baseline to week 24 changes in DAGs composed of palmitic acid (16:0), palmitoleic acid (16:1), and stearic acid (18:0) differed by serostatus (unadj- = 0.009-0.03; adj-p 0.10-0.12), with nonsignificant increases and decreases in concentrations in PWH and controls, respectively. Concentrations of individual lysophosphatidylcholine (LPC) and ceramide (CER) species also differed by HIV serostatus (unadj- < = 0.05). Although exploratory, the effects of exercise on the lipidome may differ among people with and without HIV, potentially due to underlying alterations in lipid processing and fatty acid oxidation in PWH. Clinical Trials NCT02404792.
在衰老的 HIV 感染者（PWH）中，与年龄相关的合并症和身体功能障碍可以通过运动干预得到改善。这些改善的机制，包括脂质组学的变化，目前尚不清楚。久坐的成年人（50-75 岁）无论是否感染 HIV，都参加了 24 周的监督耐力/抗阻运动。通过质谱法测量基线和第 24 周时的血浆脂质浓度（来自 13 个脂质类别的约 1200 种脂质）。考虑到多次比较，报告未经调整和 Benjamini-Hochberg 校正的值。分析被认为是探索性的。25 名 PWH 和 24 名对照者在基线和第 24 周时有配对样本。运动干预后总三酰甘油（TAG）浓度的变化在两组之间不同（未校正-=0.006，校正-=0.078），对照组的浓度升高，而 PWH 组的浓度没有升高。由长链脂肪酸组成的 TAG 种类的浓度变化在两组之间不同（未校正-<0.04），对照组的浓度升高，而 PWH 组的浓度没有升高。从基线到第 24 周，总二酰甘油（DAG）浓度的变化在两组之间不同（未校正-=0.03，校正-=0.2），PWH 组增加，对照组无显著减少。从基线到第 24 周，由棕榈酸（16:0）、棕榈油酸（16:1）和硬脂酸（18:0）组成的 DAG 的变化因血清状态而异（未校正-=0.009-0.03；adj-p 0.10-0.12），浓度分别在 PWH 和对照组中无显著增加和减少。个别溶血磷脂酰胆碱（LPC）和神经酰胺（CER）种类的浓度也因 HIV 血清状态而异（未校正-<0.05）。虽然是探索性的，但运动对脂质组的影响可能在有和没有 HIV 的人群中不同，这可能是由于 PWH 中脂质处理和脂肪酸氧化的潜在改变。临床试验 NCT02404792。
